Obesity raises the risk of asthma and asthma morbidity, according to an increasing body of research. The study examines current clinical data showing a causal connection between obesity and asthma, as well as the processes that may contribute to ‘obese asthma.’ Although obesity and asthma co-occur in some children, individuals with ‘obese asthma’ have higher asthma severity, worse quality of life, and lower treatment responsiveness. Anatomical changes in the airways, such as obstruction and dysanapsis, systemic inflammation, adipokine production, impaired glucose–insulin metabolism, altered nutrient levels, genetic and epigenetic changes, and alterations in the airway and/or gut microbiome may all be involved in the underlying mechanistic pathways. A few small studies have suggested that weight loss therapies may improve asthma outcomes, but research on therapeutic approaches for these children has been limited thus far.
Obesity raises the risk of asthma and affects asthma severity or control through a variety of processes. In children, ‘obese asthma’ is a complicated, multivariate trait. Obesity and its consequences must be addressed as part of the therapy of obese children’s asthma.
