Explaining the characteristics and the prognostic importance of isolated para-aortic lymphatic metastasis of endometrial cancer was the main objective of this study. On the basis of the Surveillance, Epidemiology, and End Results (SEER) archive, a backdated study of patients who were diagnosed with stage IIIC endometrial cancer was conducted. Three different categories were made in accordance with the lymphatic metastasis patterns: isolated para-aortic lymphatic metastasis, isolated pelvic lymphatic metastasis, and dual lymphatic metastasis; 2,767 patients were sorted into these three categories. Patients within these groups were compared on the basis of their clinic-pathological features and prognosis.

Around 13.70% of the patients were diagnosed with isolated para-aortic lymphatic metastasis. Corresponding histological characteristics were found to be mutual between the patients who had isolated para-aortic lymphatic metastasis or isolated pelvic lymphatic metastasis. The only exception here was the fact that patients who had tumors with a diameter of over 5 cm were proportionately lower in those who had isolated para-aortic lymphatic metastasis than those who had isolated pelvic lymphatic metastasis (35.1% versus 45.7%, p = 0.001). Patients who had endometrioid tumors (78.6% versus 67.3%, p < 0.001), negative peritoneal cytology (76.2% versus 61.1%, p < 0.001), and grade 1 and 2 cancers (53.3% versus 36.3%, p < 0.001) also happened to have isolated para-aortic lymphatic metastasis in comparison to patients with dual lymphatic metastasis. For the patients who were at stage IIIC, dual lymphatic metastasis was utilized as an independent factor to predict their results. However, the alike prognosis was found between patients with isolated para-aortic lymphatic metastasis and those with isolated pelvic lymphatic metastasis in the endometrioid tumors in stage IIIC. Subsets could not be created in accordance with the lymphatic metastasis patterns for the patients at stage IV and those who had non endometrioid tumors at stage IIIC.

A mutual set of clinical-pathological characteristics and prognoses is shared between the patients who have isolated para-aortic lymphatic metastasis and the patients who have isolated pelvic lymphatic metastasis.

Link:journals.sagepub.com/doi/full/10.1177/1758835920933036