South Asian (SA) Canadian immigrants are more likely than non-migrant SAs to suffer immune-mediated inflammatory disorders. Researchers wanted to see how migration affected the gut metagenome and whether there were any microbiological links between migration and factors that could influence the onset of immune-mediated inflammatory disorders. The time spent in Canada was linked to continuous alterations in gut microbial populations, according to a metagenomic investigation of 58 first-generation (GEN1) SA immigrants and 38 unrelated Canadian born children-of-immigrants (GEN2). Early childhood migration of GEN1 to Canada resulted in a gut community comparable to that of GEN2 SA Canadians and non-SA North Americans. GEN1 immigrants who just arrived in Canada, on the other hand, showed considerable differences from GEN2 despite sharing microbiological commonalities with a non-migrating SA group. High abundance taxa influenced community composition the most, according to multivariate analysis. GEN1 and non-migrant SAs were dominated by Prevotella copri. Clostridia and functionally related Bacteroidia spp. have gradually supplanted P. copri in Canada. In Canada, mutually exclusive Dialister species were found in varying relative abundances over time and generations. This change in species composition is characterized by a shift in genes involved in glucose consumption and the synthesis of short-chain fatty acids. For GEN1 recent immigrants, total energy derived from carbs was considerably higher than total energy derived from protein consumption, influencing the gut community’s functional requirements. The research shows links between migration and the gut microbiota, which may be linked to the increased risk of immune-mediated inflammatory disorders seen in South Africans.
Link:www.tandfonline.com/doi/full/10.1080/19490976.2021.1902705
