In recent decades, the prevalence of chronic inflammatory bowel disorders (IBDs) such as Crohn’s disease (CD) and ulcerative colitis (UC) has grown dramatically, perhaps due to environmental factors. The notion of the developmental genesis of illness provides a theoretical framework within which the intricate interplay between environmental variables and host cells, particularly during susceptible time periods, eventually causes disease, such as IBD. The fundamental process inside this idea has been described as epigenetics, which converts environmental stimuli into persistent alterations in cellular function. 

The gut microbiota, which is similarly susceptible to the environment and can affect host cell activity, adds to the complexity of IBD, with new studies emphasizing the stochastic and personalized character of such impacts.Researchers examine the microbiome literature in the context of IBD pathogenesis using a unique triple environmental hit paradigm (priming, modulation, and trigger). They argue that there are at least three different phases in an individual’s life where random/stochastic occurrences influenced by environmental factors are required for the development of IBD. According to the study, microbiome-directed therapies have the potential for personalized preventive and dynamic IBD treatment.