Prediabetes or intermediate hyperglycemia is a high-risk metabolic state of diabetes. Some recent cohort studies indicate that prediabetes is associated with a higher risk of atherosclerotic cardiovascular disease and all-cause mortality.

The objective of this research is to assess the association between prediabetes and the risk of incident CV disease and all-cause mortality.

This study is an updated meta-analysis that includes electronic databases like Google Scholar, Embase, and PubMed up to April 25, 2020. The research team analyzed prospective cohort studies for odds ratios, hazard ratios, and relative risks of all-cause mortality or CV disease. Two investigators extracted data independently and used random-effects models to calculate the related risks.

The research included 129 studies involving 10,069, 955 individuals. It was found that prediabetes was associated with an increased risk of all-cause mortality, stroke, coronary heart disease, and composite cardiovascular disease. Individuals with impaired glucose intolerance are at higher risk of all-cause mortality, stroke, and coronary heart disease.

In conclusion, the research indicated that prediabetes is linked with an increased risk of all-cause mortality and cardiovascular disease in the general population and in patients with atherosclerotic CV disease — the risk increases in individuals with impaired glucose intolerance. Appropriate screening and management of diabetes may help in preventing cardiovascular disease.