For a study, researchers sought to look at the progression of adrenomedullin (ADM) and endothelin-1 (ET-1) levels in patients who had a vasodilatory shock after cardiac surgery and see if there were any differences from patients who had uncomplicated coronary artery bypass graft (CABG) surgery. ADM and ET-1 were involved in the vasomotor response during a vasodilatory shock. Investigators included 32 patients with vasodilatory shock and 10 patients with uncomplicated CABG surgery (control group). MR-proADM and CT-proET-1 (stable surrogate markers for ADM and ET-1) were measured daily for the first 7 postoperative days. Compared to the control group, MR-proADM and CT-proET-1 levels in the study group were significantly higher.
Furthermore, the course of both biomarkers differed significantly between the study and control groups. Increased levels of both biomarkers were linked to organ dysfunction (higher maximum multiple organ dysfunction scores, acute kidney injury). Patients with vasodilatory shock after cardiac surgery had significantly higher levels of MR-proADM and CT-proET-1 and a different course of both biomarkers, which appeared to be associated with organ dysfunction.