Since the link between psoriasis and vitiligo had not previously been shown, for a study, researchers set out to explore it. On 22 January 2018, researchers searched the MEDLINE and EMBASE electronic databases for case-control, cross-sectional, and cohort studies exploring the relationship between psoriasis and vitiligo. The risk of bias in the listed studies was assessed using a modified Newcastle–Ottawa Scale. For case-control and cross-sectional studies, they used random-effects meta-analysis to produce pooled odds ratios (ORs) with 95% confidence intervals (CIs).

The investigation includes 10 case-control/cross-sectional studies with a total of 120,866 patients with psoriasis and 79,907 vitiligo cases from 2453 citations found in the literature. There was a substantial risk of bias in four of the studies. They discovered a considerably higher risk of vitiligo in psoriasis patients (summary OR 2.29, 95% CI: 1.56–3.37, studies=7) as well as a significantly higher risk of psoriasis in vitiligo patients (summary OR 3.43, 95% CI: 1.86–6.33, studies=4).

Psoriasis and vitiligo were linked, according to the results of the meta-analysis. A substantial risk of bias was found in several studies, indicating that further research was needed to validate the link and expand treatment choices.