Recent developments in our knowledge of the pathogenesis of atopic dermatitis (AD) have revealed that dysbiosis of the skin microbiome plays a significant role in the illness. In this review, researchers discuss how alterations in the structure and function of the microbiome play a role in the development of Alzheimer’s disease. Recent findings suggest that differences in microbial diversity, both within and between communities from distinct bodily habitats, are linked to the onset and severity of Alzheimer’s disease. They also discuss new data indicating that the skin microbiome’s metabolic activity can function as an inflammatory regulator, with changes in the amount of a skin microbiome-derived tryptophan metabolite, indole-3-aldehyde (IAId), is demonstrated to have a role in AD. 

The different ways through which interactions between the microbiota and non-histaminergic pathway components cause itch in AD are also explored.

Reference: https://link.springer.com/article/10.1007/s40257-020-00538-8