For a study, researchers sought that a systematic review was done in accordance with PRISMA, and only Level≥III evidence from the years 2000 to 2020 was taken into account. The information that was gathered includes patient demographics, the kind of botulinum toxin, dilution, dosage, injection sites and spacing, needle size and syringe, follow-up, patient and doctor evaluation, and problems. About 372 patients (average age 35.2) got various botulinum toxin injections (average 39 units/hemiface) of various dilutions by generating 0.2- to 0.5-cm wheels spaced 1 cm apart with 30- to 32-G needles, frequently with 1-mL syringes. Following up with both subjective and objective evaluations took an average of 10.5 weeks. Asymmetry of the face and mild bruises were frequent. Patients’ and doctors’ subjective assessments of the face-lifting effects were very different, and the reported injection sites varied widely. There was still a great deal of variation in dose, injection sites, “face-lifting” definitions, and assessment methods, all of which make it difficult to provide a fair and unbiased review of the data that is now available for micro-btx. Future studies should concentrate on these elements because there was an increased interest in nonsurgical procedures that have a face-lifting effect. Learn more.