Researchers studying postmenopausal women found an inverse link between decreasing body fatness from obesity in adulthood with hormone receptor-positive, luminal A-like, and overall breast cancer, according to a study published in BMC Breast Cancer Research. The study team sought to assess the age of onset, intensity, duration, and trajectories of body fatness in adulthood and determine how these data correlate to the risk for breast cancer. Using linear and mixed-effects models, the study team measured the age at onset, duration, and intensity of overweight/obesity. The authors used Cox proportional hazards models to determine HRs with 95% CIs for the links between breast cancer subtypes and BMI exposures in 148,866 postmenopausal women. Increased overweight duration and age at the onset of overweight/ obesity were correlated with luminal A-like breast cancer. The study noted heterogeneity in the link between the intrinsic-like subtypes and the age at overweight and overweight duration. Women with rising BMI trajectories were at greater risk for (HR 1.09; 95% CI 1.01–1.17) for luminal A-like breast cancer when compared with women who remained at normal weight throughout adulthood.
