Transcatheter mitral valve repair (TMVR) refers to a minimally invasive technique used in the treatment of symptomatic chronic moderate-severe mitral regurgitation (MR). Despite several developments, morbidity in patients undergoing TMVR remains to be a concern. This study aims to investigate the health status outcomes in patients undergoing TMVR.

 This cohort study included data on 4,226 patients with severe MR treated with TMVR. The primary outcome of the study was the change in disease-specific health status, as measured by the Kansas City Cardiomyopathy Questionnaire–Overall Summary score (KCCQ-OS). Factors associated with health status after 30 days and 1 year of TMVR.

The KCCQ data suggested a 69.3% survival rate at 30 days and a 47.4% survival rate at 1 year. The KCCQ-OS increased from 41.9 before TMVR to 66.7 in patients who underwent TMVR, survived at 30 days, and competed for the KCCQ at baseline. The multivariable analysis suggested that factors independently associated with lower KCCQ-OS scores were severe lung disease (−3.9), home oxygen (−2.7), atrial fibrillation (−2.2), permanent pacemaker (−2.1), and lower KCCQ scores.

The research concluded that in patients undergoing edge-to-edge TMVR, health status was impaired prior to the procedure but improved within 30 days and remained stable through 1 year.