Left atrial pressure, often known as LAP, was a great measure of how successfully the transcatheter mitral valve intervention was performed in the clinical setting. However, only the invasive measurement of LAP (i-LAP) was accessible. For a study, researchers sought to compare e-LAP to i-LAP and verify a new echocardiographic approach for estimating LAP (e-LAP). During MitraClip edge-to-edge percutaneous procedures, the i-LAP was consistently measured. Using continuous-wave Doppler echocardiography, the flow was sampled across the iatrogenic interatrial septum defect to ascertain the mean pressure gradient between the left and right atrium. Additionally, the central venous pressure was added to calculate e-LAP. A total of 34 patients were consecutively enrolled. The intraclass correlation value between e-LAP and i-LAP was strong (intraclass correlation coefficient [95% CI] 0.809 [0.625 to 0.902], R Pearson 0.6, P<0.001), and a bias of −1.3 mm Hg was identified for e-LAP relative to i-LAP (P=0.32). About 108 days was the median follow-up period (interquartile range 40 to 264). There was no fatality, and 6 patients were readmitted for heart failure. Postimplant e-LAP was associated with rehospitalization during follow-up (hazard ratio 1.46, 95% CI 1.022 to 2.1, P=0.038). As a predictor of subsequent hospitalization for heart failure, a cutoff value of 9.5 mm Hg for the e-LAP was determined to be the most effective. When compared to i-LAP, the reliability of the evaluation of e-LAP was superior; a value of more than 9.5 mm Hg was related to an increased risk of events during the short-term follow-up.

Source – ajconline.org/article/S0002-9149(22)00528-8/fulltext