The study was done to evaluate temporal trends in sexual activity and to examine associations of sexual activity with all-cause and cause-specific mortality risk.

15,269 US adults were included in analysis. In the 2015-2016 cycle, while 71.7% US adults aged 20-59 years engaged in sexual activity ≥ 12 times/year (monthly), only 36.1% of them engaged in sexual activity ≥ 52 times/year. Since the 2005–2006 cycle, the estimated prevalence of sexual activity, ≥52 times/year and ≥12 times/year, were both stable over time among the overall and each age group. During a median follow-up of 5.7 years and 71,960 person-years of observation, among 12,598 participants with eligible information on mortality status, 228 deaths occurred. Overall, participants with higher sexual activity frequency were at a lower risk of all-cause death in a dose-response manner during the follow-up period. In addition, the multivariable-adjusted hazard ratios for all-cause mortality, CVD mortality, cancer mortality, and other cause mortality among participants who had sex ≥52 times/year compared with those having sex 0–1 time/year were 0.51, 0.79 , 0.31, and 0.52, respectively.

The study concluded that the sexual activity was found to be associated with a lower risk of mortality from all causes and cancer.