Recognizing the significance of the measurement of serum tryptase as a useful tool for allergy and cell illness diagnoses was the purpose of this study. New insight of anaphylaxis mechanisms and causes is given by recent findings on the role of mast-cells and tryptase in allergic illness and other conditions. Measurement of transiently high levels of tryptases shortly after a strong reaction can help to identify the mechanism behind the reaction. A major source of global illness and death is hymenoptera venom allergy.

Venom allergy is the usual IgE-mediated effect due to sensitization to one or more venom allergens, accounting for 1.5–34% of all anaphylactic cases. The preferential link between the allergy to insect venom and mastocytosis exists. A clonal mast cell disorder is diagnosed with therapeutic implications for the therapy of the allergy of the venom. Baseline tryptase level, in conclusion, supports anaphylaxis and mast cell diseases clinically, determines venom immunotherapy and is relevant for the lifelong treatment decision.