Researchers conducted a study to examine type 2 diabetes (T2DM) as a determinant of Parkinson’s disease (PD) through a meta-analysis of observational and hereditary outline information.

A systematic review and meta-analysis of observational studies were conducted of 6 databases. The best research studies were chosen that explored the relationship of T2DM with PD risk and advancement. The researchers then utilized Mendelian randomization (MR) to explore the causal impacts of genetics toward T2DM on PD probability and progression. They used the summary information obtained from genome-wide association studies.

T2DM was linked with a higher risk of PD (OR, 1.21, 95%  CI, 1.07-1.36) in the observational part of the study, and there was some evidence that T2DM was linked to quicker advancement of movement-related symptoms (standardized mean difference [SMD], 0.55, 95% CI, 0.39-0.72) and mental decline (SMD, 0.92; 95% CI, 1.50-0.34). In addition, the researchers observed signs of a causal effect of diabetes on PD risk (inverse-variance weighted method [IVW] OR, 1.08; 95% CI; 1.02-1.14; P=0.010) and some indication of an influence on physical movements (IVW OR, 1.10; 95% CI, 1.01–1.20; P=0.032), but not on cognitive progression, using MR.

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