The goal of this study was to better understand the acceptability of the Human Papillomavirus (HPV) vaccination among Mexican adults, including those with and without HIV, cisgender males who have sex with men (MSM) or with women (MSW), and cisgender and transgender women. A computer-assisted, self-administered questionnaire was completed by healthcare consumers and participants recruited through community groups, and the first dose of the quadrivalent HPV vaccination was provided at no cost at a large sexual health clinic in Mexico City. There were 1341 cisgender men, 396 cisgender women, and 178 transwomen among the 1915 participants, and 615 were HIV positive. Men and transwomen were more likely to receive the HPV vaccination than cisgender women. Cisgender women were less likely than males to embrace HPV vaccination. When compared to singles, married/partnered persons were less likely to accept the HPV vaccine. HIV-positive people were not substantially more inclined to accept HPV vaccination.

Acceptance of the HPV vaccination was high among adult Mexican study participants; it may be greater than among other Mexican adults because the majority of these people are in care. If healthcare professionals are to promote the vaccine to the demographic groups examined, national and international recommendations on HPV immunization in adults will need to be modified.