Data are scarce on uveitis in juvenile psoriatic arthritis (JPsA), a subtype of juvenile idiopathic arthritis (JIA). The frequency and risk factors for JPsA-associated uveitis are discussed (JPsA-U).

To describe JPsA-U and identify risk factors for the development of uveitis, researchers examined cross-sectional data from the German National Pediatric Rheumatological Database (2002-2014).

In 6.6% of the 1,862 JPsA patients, uveitis occurred. Patients with JPsA-U were considerably more likely to be female (73.0 vs. 62.9%, P=0.03), antinuclear antibody (ANA) positive (60.3 vs. 37.0%, P<0.001), younger at JPsA start (5.3±4.1 vs. 9.3±4.4 yrs, P<0.001), and treated with disease-modifying antirheumatic medications (DMARDs). Multivariable analysis of 655 participants entered in the research less than or around 1 year after arthritis began revealed that the mean clinical Juvenile Arthritis Disease Activity Score for 10 joints during study recording was substantially linked with the development of uveitis. Children with early-onset JPsA (aged <5 yrs vs. ≥ 5 yrs) were significantly more likely to be ANA positive (48.4% vs. 35.7%, P<0.001), affected by uveitis (17.3% vs. 3.8%, P<0.001), and treated with DMARDs (52.9% vs. 43.8%, P<0.001), but less frequently affected by skin disease (55.3% vs 61.0%, P=0.03).

Those with JPsA who develop uveitis have comparable features to patients with uveitis in other JIA groups, such as oligoarticular JIA. Children with early-onset JPsA are more likely to have ocular involvement.

Reference: jrheum.org/content/49/7/719