For a study, researchers sought to analyze whether there was an improvement in oxidative stress (OS), as assessed by the MiOXSYS technology, following varicocele repair.

Male participants 18 years and older with clinically visible varicocele, who did not father a child for the past 12 months and who fulfilled all research requirements, were enrolled through a couple’s reproductive facility with on-site andrology laboratory testing and underwent a prospective clinical trial. After having a history and physical examination, males who met the inclusion criteria were given the opportunity to engage in the clinical study and signed informed consent to participate. Prior to surgery, an OS measurement was taken from the menstrual fluid, and 3 months later, another OS measurement was taken from the same menstrual fluid. When available, sperm DNA fragmentation (SDF) indices, static oxidation-reduction potential (sORP), and postoperative semen analytical parameters were compared to their preoperative values.

About 49 of the 177 subjects met the requirements for inclusion. The OS data hints at adverse associations with the main semen characteristics. After varicocele correction, both semen parameters and OS showed statistically significant improvements from baseline. Around 22 of the 49 included participants finished the postoperative testing in its entirety. A subgroup study reveals OS and semen parameter negative statistically significant relationships. In comparison to preoperatively, forward progressive motility, SDF, and sORP showed statistically significant improvements 3 months after varicocele resection.

Infertile males who had varicocele repairs had higher sORP values as determined by the therapeutically practical MiOXSYS technology.