For a study, researchers sought to decide if VDPhys/VT is related to coagulation activation and results. They selected patients with COVID-19 pneumonia who were upheld by invasive mechanical ventilation and were observed utilizing volumetric capnography. Estimations were performed during the initial 24 h of mechanical ventilation. The virtual endpoint was the probability of being released alive on day 28. About 60 patients were selected, of which 25 (42%) had high VDPhys/VT (>57%). Patients with high versus low VDPhys/VT had higher APACHE II (10[8-13] versus 8[6-9] focuses, P=0.002), lower static consistency of the respiratory framework (35[24-46] mL/cmH2O vs. 42[37-45] mL/cmH2O, P=0.005), and higher D-dimer levels (1,246[1,050-1,594] ng FEU/mL vs. 792[538-1,159] ng FEU/mL, P=0.001), without contrasts in P/F proportion (157[112-226] vs. 168[136-226], P=0.719). Moreover, D-dimer levels are connected with VDPhys/VT (r=0.530, P<0.001); however, not with the P/F proportion (r=−0.103, P=0.433). Patients with high VDPhys/VT were less inclined to be released alive on day 28 (32% vs. 71%, aHR = 3.393[1.161-9.915], P=0.026). In fundamentally sick COVID-19 patients, expanded VDPhys/VT was related to high D-dimer levels and a lower probability of being released alive. Dichotomic VDPhys/VT could assist with distinguishing a high-risk subgroup of patients dismissed by the P/F proportion.