This study aimed to investigate if deficiency of VD3 is associated with the presence of NP in patients with CT and patients with CRS.

One hundred fifty-two adult participants participated in five phenotypic groups. The serum levels of 25(OH)-VD3 <20 ng/mL are considered a deficiency, 21–29 ng/mL as insufficiency, and >30 ng/mL sufficiency. Endoscopic and imaging staging of the mucosal disease was performed with the Lund-Kennedy (LK) and Lund-Mackay (LM) scoring systems. The genotype of the patients with CT and the nasal microbial colonization of the patients with CT and patients with CRS were also recorded.

Moreover, the LK endoscopic scores had a similar correlation in the CT groups; however, this was not the case with the CRS groups.

The study concluded that VD3 deficiency seemed to be associated with nasal polyps in patients with CRS and CT patients in a similar manner. The lower the serum VD3, the more severe the mucosal disease was found in the imaging studies and the more frequent microbial colonization of the patients with CT and the patients with CRS.

Reference: https://journals.sagepub.com/doi/full/10.2500/ajra.2017.31.4484