Although allergic asthma is a common chronic inflammatory illness, the underlying pathophysiology that causes Th2 type inflammation remains unknown. Although Wnt/-catenin signaling has been implicated, the impact of specific components of the pathway is unknown. According to researchers’ findings, secreted Frizzled Related Protein-1 (SFRP-1), a Wnt signaling regulator, may play a role in developing allergic inflammation in asthma. SFRP-1-/- mice were sensitized in an in vivo home dust mite asthma paradigm, and they collected their bronchoalveolar lavage fluid to assess airway inflammation. Compared to wild-type (WT) mice, SFRP-1-/- mice showed less inflammation, with lower cellular infiltration and IL-5 levels in bronchoalveolar lavage fluid.
WT mice treated with the SFRP-1 inhibitor WAY316606 showed similar results. Compared to wild WT, alveolar macrophages from sensitized SFRP-1-/- animals showed reduced alternative polarisation, indicating that macrophages may underlie the change in inflammation seen in these mice. These findings point to SFRP-1 as a key mediator of asthmatic airway inflammation.
Reference:www.atsjournals.org/doi/abs/10.1165/rcmb.2020-0314OC
