Machine learning for genetic prediction of psychiatric disorders: a systematic review.
Machine learning methods have been employed to make predictions in psychiatry from genotypes, with...
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Month: June 2020
Intentional Self Harm in Children with Autism.
The study examined the demographic, socioeconomic, and clinical correlates of self injurious...
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Elevated serum neurofilament light chain in children autism spectrum disorder: a case control study.
We aimed to assess serum neurofilament light chain (sNfL) levels in autism spectrum disorder (ASD)...
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The β-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak α-adrenoceptor antagonists.
Recently, the β-adrenoceptor agonist terbutaline was shown to have α-adrenolytic activity in mouse...
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Phenotype variability and different genotype of four patients with thyroid hormone resistance syndrome due to variants in the THRB gene.
Resistance to thyroid hormone (RTH) is a rare dominantly inherited disorder mainly due to...
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Blockade of CCR4 DIminishes hypersensitivity and enhances opioid analgesia – evidence from a mouse model of diabetic neuropathy.
Chemokine signaling has been implicated in the pathogenesis of diabetic neuropathy; however, the...
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Chemogenetic silencing of neurons in the mouse anterior cingulate area modulates neuronal activity and functional connectivity.
The anterior cingulate area (ACC) is an integral part of the prefrontal cortex in mice and...
Read MoreEfficacy of adding midazolam to paracetamol in pain control of patients with a primary headache: A randomized, clinical trial study.
This study aimed to determine the effect of adding intravenous midazolam to paracetamol in the treatment of patients with primary headache referring to the emergency department.In a randomized clinical trial, 120 patients (18-65...
Read MoreSerum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study.
Reduced blood or cerebrospinal fluid levels of allopregnanolone are involved in menstrual cycle-linked CNS disorders, such as catamenial epilepsy. This condition, like menstrually-related migraine, is characterized by severe,...
Read MoreCranial Autonomic Symptoms of Migraine in Japan: Prospective Study of 373 Migraine Patients at a Tertiary Headache Center.
To clarify the detailed clinical characteristics of cranial autonomic symptoms (CAS) of Japanese patients with migraine and to get insight into the pathophysiological implications.Recent studies reported that CAS in migraine is...
Read MoreNon-specific analgesia during a clinical trial in fibromyalgia.
When patients suffering from fibromyalgia undergo a therapeutic trial, a non-negligible part of analgesia is not explained by the drug itself. The mechanisms of this non-specific effect need to be understood.We undertook...
Read MoreComorbid Conditions, Mental Health and Cognitive Functions in Adults with Fibromyalgia.
This study examined age group differences across adulthood in comorbid conditions, mental health, and cognitive function in people with fibromyalgia. Participants completed an online survey about how fibromyalgia affects their...
Read MoreExploring Pain-Related Anxiety and Depression in Female Patients With Provoked Vulvodynia With Associated Overactive Pelvic Floor Muscle Dysfunction.
Vulvodynia is a chronic pain condition with potential associated factors, including musculoskeletal and psychosocial components.This study explores the prevalence of pain-related anxiety and depression in women with provoked...
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Biochemical assay and spectroscopic analysis of oxidative/antioxidative parameters in the blood and serum of substance use disorders patients. A methodological comparison study.
Substance abuse such as opioids, cannabis, and alcohol causes activation on the immune system and...
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Risk factors of unplanned neurosurgery for scoliotic patients with Chiari malformation type I and syringomyelia after spinal deformity correction.
It remains unclear which subgroups of scoliotic patients with CMI and syringomyelia are more...
Read MoreA novel approach to production of Chlorella protothecoides oil loaded nanoparticles via electrospraying method: Modelling of critical parameters for particle sizing.
Bioactive compounds in algae, have chain rings that protect the tissue from chemical damage and disease symptoms. In addition, algal bioactive agents have the ability to stimulate the immune system, protective and therapeutic...
Read MoreStatins and autoimmunity: State-of-the-art.
HMG-CoA reductase inhibitors, or statins, are potent plasma LDL-cholesterol (LDL-c) lowering agents. Since the introduction of the first statin, lovastatin, in 1987, accumulating evidence showed that non-cholesterol lowering...
Read MoreDevelopment and Psychometric Evaluation of the PROMIS® Pediatric Pain Intensity Measure in Children and Adolescents with Chronic Pain.
The goal of the current study was to enhance the measurement of the pediatric chronic pain experience through a methodologically rigorous approach. This paper outlines the development and initial validation of a pain intensity...
Read MoreExercise interventions for persistent non-specific low back pain – does matching outcomes to treatment targets make a difference? A systematic review and meta-analysis.
Exercise is a core treatment for persistent non-specific low back pain (NSLBP), but results from randomised controlled trials (RCTs) of exercise typically show only small to moderate standardised mean differences (SMDs) compared...
Read MoreInter-individual differences in the responses to pain neuroscience education in adults with chronic musculoskeletal pain: A systematic review and meta-analysis of randomised controlled trials.
Pain neuroscience education (PNE) is an approach used in the management of chronic musculoskeletal pain (CMP). Previous reviews on PNE and other pain interventions, have focussed on mean treatment effects, but in the context of...
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