Food protein induced enterocolitis (FPIES) is a syndrome with heterogeneous features (i.e., age at presentation, severity, food triggers, comorbidities) and is not as rare as initially believed. Over the last few years, the first population-based epidemiological study, few prospective birth cohort assessing FPIES prevalence, and several larger (>100 patient) studies have been published, making epidemiological estimation more reliable. In this review, we report on the available data on the epidemiology of FPIES.
PubMed review using words FPIES, Epidemiology, and Prevalence STUDY SELECTIONS: Review focused on population-based epidemiological study, few prospective birth cohort assessing FPIES prevalence, and several larger (>100 patient) studies RESULTS: We identified eight population or cohort studies CONCLUSION: FPIES is not a rare in both children and adults and may affect as many as 900,000 people in the US alone. Most children and adult with FPIES appear to react to 1-2 foods, however they may need further diet restriction due high level of comorbidity with IgE mediated food allergies and Eosinophilic Esophagitis. Globally cow’s milk, rice/oat and seafood appear to be the most common triggers.

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