Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer- testis antigens and is common in various types of cancers.
in this study, for the first time, we performed immunohistochemical analysis to evaluate the expression of MAGE-A3 in 153 prostate tissue samples including prostate cancer (PCa), benign prostatic hyperplasia (BPH) and high-grade prostatic intraepithelial neoplasia (HPIN).
Increased Both nuclear and cytoplasmic expression of MAGE-A3 was significantly found in PCa tissues compared to both HPIN and BPH tissues (nuclear expression at P=0.011, and cytoplasmic expression at p=0.034; for both comparisons P<0.0001, respectively). A significant correlation was observed between higher nuclear and cytoplasmic expressions of MAGE-A3 with Gleason score (P 7) were independent predictors of the DFS (both; P=0.019). Nuclear expression of MAGE-A3 was also significantly related to BCR-FS (P=0.015).
MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa.
This article is protected by copyright. All rights reserved.
About The Expert
Azadeh Khalvandi
Maryam Abolhasani
Zahra Madjd
Mehdi Shekarabi
Masoumeh Kourosh-Arami
Monireh Mohsenzadegan
References
PubMed