Bone health in older individuals with HIV infection is not well studied. This study aimed to compare bone mineral density(BMD), trabecular bone score(TBS), and bone markers in HIV-infected- with age-matched and body mass index(BMI)-matched HIV-uninfected men aged ≥60 years. We investigated the associations between risk factors related to fracture and BMD, TBS, and bone markers in HIV-infected men.
This cross-sectional study included 45 HIV-infected men receiving antiretroviral therapy and 42 HIV-uninfected men. Medical history, BMD and TBS measurements, and laboratory tests related to bone health were assessed in all participants. HIV-related factors known to be associated with bone loss were assessed in HIV-infected men.
Mean BMD and TBS, and osteopenia/osteoporosis prevalence were all similar among cases and controls. HIV-infected men had significantly higher mean N-terminal propeptide of type 1 procollagen and C-terminal cross-linking telopeptide of type I collagen (CTX). Stepwise multiple linear regression analysis demonstrated that a low BMI (P=0.015 at lumbar spine, P=0.018 at femoral neck, and P=0.005 at total hip), high CTX (P=0.042 at total hip and P=0.010 for TBS), and a low amount of vitamin D supplementation (P=0.035 for TBS) were independently associated with a low BMD and TBS.
In older HIV-infected men with a low fracture risk, mean BMD and TBS were similar to age- and BMI-matched controls. Mean bone markers were higher in the HIV group. Traditional risk factors for fracture, including low BMI, high CTX, and low vitamin D supplementation were significant predictors of a low BMD and TBS.

Copyright © 2021. Published by Elsevier Inc.