Currently, there are still no early biomarkers to detect infants with risk of autism spectrum disorder (ASD), which is mainly diagnosed based on behavioral observations at three or four years of age. Since intervention efforts may miss a critical developmental window after 2 years old, it is clinically significant to identify imaging-based biomarkers at an early stage for better intervention, before behavioral diagnostic signs of ASD typically arising. Previous studies on older children and young adults with ASD demonstrate altered developmental trajectories of the amygdala and hippocampus. However, our knowledge on their developmental trajectories in early postnatal stages remains very limited. In this paper, for the first time, we propose a volume-based analysis of the amygdala and hippocampal subfields of the infant subjects with risk of ASD at 6, 12, and 24 months of age. To address the challenge of low tissue contrast and small structural size of infant amygdala and hippocampal subfields, we propose a novel deep-learning approach, dilated-dense U-Net, to digitally segment the amygdala and hippocampal subfields in a longitudinal dataset, the National Database for Autism Research (NDAR). A volume-based analysis is then performed based on the segmentation results. Our study shows that the overgrowth of amygdala and cornu ammonis sectors (CA) 1-3 May start from 6 months of age, which may be related to the emergence of autistic spectrum disorder.
Primary Care Physician Characteristics Associated with Prescribing Potentially Inappropriate Medication for Elderly Patients: Medicare Part D Data.
July 20, 2020
February 13, 2020
- ACC 2020The American College of Cardiology decided to cancel ACC.20/WCC due to COVID-19, which was scheduled to take place March 28-30 in Chicago. However, ACC.20/WCC Virtual Meeting continues to release cutting edge science and practice changing updates for cardiovascular professionals on demand and free through June 2020.
- ENDO: 2020ENDO 2020 Annual Conference has been canceled due to COVID-19. Here are highlights of emerging data that has still been released. Keep an eye out for ENDO Online 2020, which will take place from June 8 to 22.
- AAN 2020Due to the global COVID-19 pandemic, the American Academy of Neurology had to cancel the AAN’s Annual Meeting originally scheduled for April 25–May 1, 2020, in Toronto.