There is limited current knowledge on feasibility and safety of kidney transplantation in COVID-19 survivors.
We present a retrospective cohort study of 75 kidney transplants in patients who recovered from polymerase chain reaction (PCR) confirmed COVID-19 performed across 22 transplant centers in India from July 3, 2020 to January 31, 2021. We detail demographics, clinical manifestations, immunosuppression regimen, laboratory findings, treatment and outcomes. Patients with a previous diagnosis of COVID-19 were accepted after documenting 2 negative SARS-CoV-2 PCR tests, normal chest imaging with complete resolution of symptom for at least 28 days and significant social distancing for 14 days prior to surgery.
Clinical severity in patients ranged from asymptomatic (n=17, 22.7%), mild(n=36,48%), moderate(n=15,20%) and severe(n=7,9.3%) disease. Median duration between PCR positive to transplant was 60 days (overall) and, increased significantly from asymptomatic, mild, moderate and severe disease (49,57,83,94 days, P-value 0.019) respectively. All recipients and donors were asymptomatic with normal creatinine after surgery at a median (interquartile range) follow up of 81 (56-117) days without any complications relating to surgery or COVID-19. Patient and graft survival was 100%, and acute rejection was reported in 6.6%.
Prospective kidney transplant recipients post-COVID-19 can be considered for transplantation after comprehensive donor and recipient screening before surgery using a combination of clinical, radiologic, and laboratory criteria, careful pre-transplant evaluation, and individualized risk-benefit analysis. Further large-scale prospective studies with longer follow-up will better clarify our initial findings. Till date, this remains the first largest study of kidney transplantation in COVID-19 survivors.Supplemental Visual Abstract; http://links.lww.com/TP/C180.
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
About The Expert
Vivek B Kute
Deepak S Ray
Dinesh Kumar Yadav
Vivek Pathak
Anil K Bhalla
Suraj Godara
Anil Kumar
Sandeep Guleria
Dinesh Khullar
Sharmila Thukral
Rabi Ranjan Sow Mondal
Manish Jain
Pranaw Kumar Jha
Umapati Hegde
Abi Abraham M
Sonal Dalal
HImanshu Patel
Madan M Bahadur
Ashay Shingare
Ashish Sharma
Raj Kumar Sharma
Urmila Anandh
Sanjeev Gulati
Manoj Gumber
Vishwanath Siddini
Rushi Deshpande
Kamal Kaswan
Umesh Varyani
Shailesh Kakde
Deepesh B Kenwar
Hari Shankar Meshram
Vijay Kher
References
PubMed