Background and Objectives Dermatochalasis (DC) is part of the aging process of the eyelids, characterized by lax, redundant, overhanging excess eyelid skin. Mostly it is treated by surgical blepharoplasty. Lately alternative alternative non-surgical blepharoplasty technologies have been introduced. In this study we evaluated the efficacy and safety of a novel non-invasive RF microplasma technology for upper eyelid DC. A prospective single center study included 17 patients with moderate to severe upper eyelid DC. Subjects were treated by controlled micro-plasma sparks via a single tip leading to superficial ablation and coagulation at the treatment area. One to three treatment sessions at 2 months interval were performed. Three blinded observers evaluated the photographs taken at baseline and at 6-8 months follow up visit following the final treatment session. Treatment efficacy was assessed using a 4-point grading scale. Seven out of 17 patients (41%) treated for DC by the single microplasma spark exhibited a 2 grade improvement on a 4 point DC scale. 10 out of 17 (59%) patients showed a single grade improvement on a 4 point DC scale. No adverse side effects were observed. Non-invasive ablative microplasma may offer safe and effective therapy for upper eyelid DC. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.