Flaviviruses including Zika virus, Dengue virus, Japanese Encephalitis virus and Yellow Fever virus cause heavy burdens to public health around the world. No specific antiviral drug was available in clinic against these flavivirus infections. Heat-shock protein 70 (HSP70) has recently been proven to be a promising antiviral target against Zika virus and Dengue virus. Here, we report that, Apoptozole, a small molecule inhibitor of ATPase activity of HSP70 has broad-spectrum anti-flavivirus potential. The mode of action analysis revealed that Apoptozole acted at post-entry step. Transcriptome analysis revealed that genes related to cholesterol metabolism, fatty acid synthesis and innate immunity were differentially expressed after treatment of Apoptozole. In vivo data suggested Apoptozole exerted protection effects against ZIKV infection in mouse model by enhancing innate immune response, which suggested a novel anti-ZIKV mechanism of HSP70 inhibitors. Key words: Flavivirus, Antiviral, Apoptozole, Zika virus, Innate immunity.
Related Posts
Advertisement
Meeting Coverage
- ACC 2020The American College of Cardiology decided to cancel ACC.20/WCC due to COVID-19, which was scheduled to take place March 28-30 in Chicago. However, ACC.20/WCC Virtual Meeting continues to release cutting edge science and practice changing updates for cardiovascular professionals on demand and free through June 2020.
- CROI 2020Every year, CROI hosts some of the world's leading experts in HIV research, who come to present exciting new data and drive forward the field of HIV/AIDS research. This year, due to COVID-19, CROI held their meeting virtually.