Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders that co-occur with a bad fever after midday.
To evaluate the acute and 28-day subacute toxicity of an aqueous extract of SRD using in vivo methods.
To determine acute toxicity, SRD was administered by gavage at a dosage of 58.5 g/kg/day to male and female mice for 7 days. To determine subacute toxicity, SRD was administered at 3.3, 6.5, or 13 g/kg/day to male and female rats for 28 days. The general behavior, body weight, biochemical and hematological parameters, organ coefficients and pathological morphology of the treated animals were analyzed.
Neither acute nor subacute concentrations of SRD caused significant changes in the body weights, general behavior, hematology and biochemical parameters, organ weights, or histopathological appearances of the liver, kidney, spleen, brain, lung or heart in mice or rats.
The administration of SRD can be considered safe within the conditions of this study.
Copyright © 2021. Published by Elsevier B.V.
About The Expert
Qing Wang
Liutao Zhao
Hui Zhang
Shuo Zhang
Pu Yang
Huanhuan Wang
Qingyan Yuan
Guanlian Wu
Chunli Wu
References
PubMed