To evaluate the association of pretreatment maximum standardized F-fluorodeoxyglucose uptake value (SUV ) of cervix and serum squamous cell carcinoma antigen (SCC-ag) with FIGO2018 stage and prognosis among women with Stage IIB-IVB squamous cervical cancer.
Retrospective study of 116 women with FIGO2018 Stage IIB-IVB cervical cancer treated in Hangzhou, China, 2013-2015. The relationship between pretreatment SUV or SCC-ag and prognostic factors was evaluated by univariate and multivariate analyses.
Women were stratified by mean SUV and mean SCC-ag. There was a significance difference between low (<12.9) and high (≥12.9) SUV groups in menopause (P=0.004), FIGO2018 stage (P=0.015), and survival rate (P<0.001). The low group had better overall and progress-free survival by Kaplan-Meier evaluation (both P=0.022). High SCC-ag (≥14.6 ng/mL) was associated with FIGO2018 stage (P=0.038) and distant metastasis (P=0.011). There was a significant correlation between SUV and serum SCC-ag (P=0.026). In multivariate Cox regression analyses, FIGO2018 stage (P=0.019) and SUV of cervix (P=0.015) were independent predictors of poor outcome in squamous cervical cancer.
Both SUV of cervix and SCC-ag were associated with FIGO2018 stage in squamous cervical cancer. Pretreatment high SUV of cervix and advanced FIGO2018 stage might indicate a poor prognosis.
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