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Skin Cancer

#VisualAbstract: Combination of spartalizumab plus dabrafenib and trametinib does not significantly improve survival in BRAFV600-mutated metastatic melanoma

Jul 28, 2022

Click to read this study in the Journal of Clinical Oncology.  ...

Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy.

May 23, 2022

Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have ...

#VisualAbstract: Severe Actinic Keratosis and Need for Additional Treatment Are Markers for Increased Risk for Cutaneous Squamous Cell Carcinoma

May 21, 2022

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An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma.

May 16, 2022

Laryngeal squamous cell carcinoma (LSCC) is the most common squamous cell carcinoma. Though significant effort has been focused on molecular pathogenesis, development, and recurrence of LSCC, little i...

Evaluation of anti-proliferative activity of Eryngium caucasicum on melanoma cancer cells.

May 16, 2022

The genus Eryngium is a member of the Apiaceae family that has shown different pharmacological effects mainly including anti-inflammatory, analgesic, anti-cancer, hepatoprotective, and anti-oxidant. P...

Association between high immune activity and worse prognosis in uveal melanoma and low-grade glioma in TCGA transcriptomic data.

May 09, 2022

Immune status in the tumor microenvironment is an important determinant of cancer progression and patient prognosis. Although a higher immune activity is often associated with a better prognosis, this...

Identification of novel key regulatory lncRNAs in gastric adenocarcinoma.

May 09, 2022

Stomach adenocarcinoma (STAD) is one of the most common and deadly cancers worldwide. Recent evidence has demonstrated that dysregulation of long noncoding RNAs (lncRNA) is associated with different h...

Agent-based Modeling of Tumor and Immune System Interactions in Combinational Therapy with Low-dose 5-fluorouracil and Dendritic Cell Vaccine in Melanoma B16F10.

May 02, 2022

This study is designed to present an agent-based model (ABM) to simulate the interactions between tumor cells and the immune system in the melanoma model. The Myeloid-derived Suppressor Cells (MDSCs) ...

Prevalence of wound complications following Mohs micrographic surgery: a cross-sectional study of 1000 patients undergoing Mohs surgery and wound repair in a UK teaching hospital.

May 02, 2022

Mohs micrographic surgery (MMS) for non-melanoma skin cancer is often quoted as having an excellent safety profile.(1) Determine the complication rate of patients undergoing MMS in a large UK Mohs uni...

#VisualAbstract: Dermatopathologists have varying perceptions on whether the overdiagnosis of different melanocytic skin lesions is a public health issue

Apr 29, 2022

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#VisualAbstract: Ruxolitinib use may be associated with higher incidences of nonmelanoma skin cancers

Apr 27, 2022

Click to read this study in the Journal of the American Academy of Dermatology. ...

Linc-ROR genetic variants are associated with the advanced disease in oral squamous cell carcinoma.

Apr 25, 2022

The objective of this study is to identify the association between linc-ROR genetic variants and oral squamous cell carcinoma tumorigenesis.Four genetic variants of linc-ROR (rs6420545, rs4801078, rs1...

RASD2 promotes the development and metastasis of uveal melanoma via enhancing glycolysis.

Apr 25, 2022

Uveal melanoma (UVM) is a primary intraocular tumor in adults with high mortality. Nearly half of primary UVM tumors metastasize to the liver and lung. RASD2 encodes a Ras-related GTP-binding protein ...

Synthesis and anticancer activity in vitro and in vivo evaluation of iridium(III) complexes on mouse melanoma B16 cells.

Apr 18, 2022

Combining the ligand NPIP (2-(2-nitrophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline) with piq (1-phenylisoquinoline) and bzq (benzo[h]quinolone) gave [Ir(piq)(NPIP)](PF) (Ir1), and [Ir(bzq)(NPIP)](PF) ...

Acral lentiginous melanoma histotype predicts outcome in clinical stage I-II melanoma patients: an International multicenter study.

Apr 18, 2022

In the American Joint Committee on Cancer (AJCC) classification, acral lentiginous melanoma (ALM) histotype ALM is not included as an independent prognostic factor; in small series its negative progno...

Skeletal muscle is prognostic in resected stage III malignant melanoma.

Apr 11, 2022

Sarcopenia (low skeletal muscle index, SMI) and myosteatosis (low skeletal muscle radiodensity, SMD) have been associated with worse survival in cancer. This study evaluated associations of body compo...

Low body mass index is associated with reduced intratumoral CD4 T-lymphocyte infiltration in laryngeal squamous cell carcinoma patients.

Apr 04, 2022

Tumor size, inflammation, and nutritional status may be correlated with the immune response to cancer. Our hypothesis is that there is an interrelationship among tumor size, inflammatory response, and...

#VisualAbstract: Systematic review shows a lack of high-quality evidence on the association between UV exposure and keratinocyte carcinoma development in skin of colour

Apr 01, 2022

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Metastatic melanoma to the small bowel causing intussusception: A case report.

Mar 28, 2022

Melanoma is a malignant skin neoplasm with a high metastatic potential. Several reports have shown that metastatic melanoma has a predilection to metastasize to the GI tract; however, diagnosing metas...

RNA in situ hybridisation as a molecular diagnostic technique targeting IBA-1 and CD204 in canine histiocytic sarcoma.

Mar 28, 2022

Canine histiocytic sarcoma (HS) is an aggressive cancer with morphologically variable features; therefore, obtaining a definitive diagnosis can be challenging. Two proteins, IBA-1, ionised calcium-bin...