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Skin Cancer

Tumour- associated autoantibodies as prognostic cancer biomarkers- a review.

Jan 17, 2022

Throughout the process of carcinogenesis, autologous cells are transformed into cancer cells, leading to changes in their protein expression profiles. It has been suggested that mutations, protein mis...

An injectable superior depot of Telratolimod inhibits post-surgical tumor recurrence and distant metastases.

Jan 17, 2022

The clinical success of Toll-like receptor (TLR) agonists is based on their capacity to efficiently mobilize both innate and adaptive immunity. However, rapid distribution of TLR agonists into the sys...

Changing characteristics, treatment approaches and survival of patients with brain metastasis: data from six thousand and thirty-one individuals over an observation period of 30 years.

Jan 10, 2022

An accurate classification of patients with brain metastases (BMs) is an important foundation to guide individualised treatment decisions and to formulate BM cohorts for modern clinical trials.Six tho...

Closure of radial forearm free flap donor-site defect with proportional local full-thickness skin graft: case series study of a new design.

Jan 03, 2022

The aim of this study was to describe a simple, convenient, and reliable new technique using local full-thickness skin graft (FTSG) for skin coverage of a donor-site defect of the radial forearm free ...

PD-L1 expression is regulated by microphthalmia-associated transcription factor (MITF) in nodular melanoma.

Dec 27, 2021

Malignant melanoma (MM) is known to avoid the host's immune response. Studies on in vitro melanoma cell lines link the microphthalmia-associated transcription factor (MITF) with the regulation of the ...

Role of Esophagectomy after Chemoradiation Therapy in Patients with Locally Advanced Squamous Cell Carcinoma: A Comparative Analysis Stratified by Clinical Response to Chemoradiation Therapy.

Dec 27, 2021

This study aimed to evaluate the long-term effect of esophagectomy in patients with esophageal squamous cell carcinoma (ESCC) by comparing the chemoradiotherapy (CRT)-only group and the trimodality tr...

Multifunctional Immunoliposomes Enhance the Immunotherapeutic Effects of PD-L1 Antibodies against Melanoma by Reprogramming Immunosuppressive Tumor Microenvironment.

Dec 20, 2021

The immunosuppressive tumor microenvironment (TME) can significantly limit the immunotherapeutic effects of the PD-L1 antibody (aPDL1) by inhibiting the infiltration of CD8 cytotoxic T cells (CTLs) in...

Lighter Eye Color Linked With Increased Risk for Skin Cancer

Dec 13, 2021

“Lighter pigmentary traits, such as lighter hair, lighter skin, and severe skin reaction following sun exposure, have been tied to higher risk for skin cancers,” explains Eunyoung Cho, ScD. “How...

Novel PTCH1 and concurrent TP53 mutations in four patients with numerous non-syndromic basal cell carcinomas: The paradigm of oncogenic synergy.

Dec 06, 2021

There has been a significant increase in basal cell carcinoma (BCC) incidence, the most common cancer in humans, and the age of presentation with the first diagnosis of BCC has decreased in past decad...

Digital dermoscopy monitoring of melanocytic lesions: Two novel calculators combining static and dynamic features to identify melanoma.

Dec 06, 2021

Early diagnosis is the most effective intervention to improve the prognosis of cutaneous melanoma. Even though the introduction of dermoscopy has improved the diagnostic accuracy, it can still be diff...

Sunscreen Does Not Increase Risk for Osteoporotic Fracture

Nov 29, 2021

“For many years, there have been serious concerns among the medical and lay communities surrounding the use of sunscreen and other sun-protective measures with regard to their potentially detrimenta...

High-throughput ex vivo drug testing identifies potential drugs and drug combinations for NRAS-positive malignant melanoma.

Nov 29, 2021

Therapy options for patients with metastatic melanoma (MM) have considerably improved over the past decade. However, many patients still need effective therapy after unsuccessful immunotherapy, especi...

PRAME Immunohistochemistry as an Adjunct for Differential Diagnosis in Acral Lentiginous Melanoma and Acral Nevi.

Nov 22, 2021

Preferentially expressed antigen in melanoma (PRAME) has shown promising utility in distinguishing benign melanocytic lesions from melanomas, but knowledge of its expression pattern in acral lentigino...

Prognostic impact of extranodal extension in resected head and neck squamous cell carcinomas in the era of postoperative chemoradiation: A retrospective monocentric study.

Nov 22, 2021

For patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC), surgery (S) followed by radiotherapy (RT) is a standard of care. Randomized controlled trials have shown that postop...

A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.

Nov 15, 2021

Our previous big data analyses showed a high level of association between chitinase-3-like protein 1 (CHI3L1) expression and lung tumor development. In the present study, we investigated whether a CHI...

The utility of high-risk human papillomavirus in situ hybridization in cytology cell block material from cystic head and neck lesions.

Nov 15, 2021

Human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV-OPSCC) presents frequently as metastasis in a neck lymph node that may be cystic or necrotic. Fine-needle aspiration (FNA) biops...

NF1-mutated melanomas reveal distinct clinical characteristics depending on tumour origin and respond favourably to immune checkpoint inhibitors.

Nov 08, 2021

NF1-mutated tumours represent a small subset (10-15%) of melanomas, not sufficiently analysed in large clinical cohorts. This study investigated the largest multicentre collection of NF1-mutated melan...

Cutaneous melanoma attributable to UVR exposure in Denmark and Germany.

Nov 08, 2021

Increasing incidence rates of cutaneous melanoma (CM) observed during the last five decades in white populations are largely attributed to increased exposure to solar ultraviolet radiation (UVR), ofte...

Characterization of the immune response in patients with cancer of the oral cavity after neoadjuvant immunotherapy with the IRX-2 regimen.

Nov 01, 2021

IRX-2 is a homologous cell-derived multi-cytokine biologic with multifaceted immune modulatory effects that has been shown to induce increased lymphocyte infiltration into primary tumors in oral cavit...

Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.

Nov 01, 2021

Human papillomavirus type-16 (HPV16) is classified into lineages, A, B, C and D and 10 sub-lineages portraying variable infectivity, persistence, and cytological outcomes, however, with geographical v...