Mohs Micrographic Surgery for CSCC
Few prospective studies on outcomes in CSCC have been performed, and outcomes for patients treated...
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Skin Cancer
Discovery of indoximod prodrugs and characterization of clinical candidate NLG802.
A series of different prodrugs of indoximod, including estesrs and peptide amides were synthesized with the aim of improving its oral bioavailability in humans. The pharmacokinetics of prodrugs that were stable in buffers,...
Read MoreComprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma.
Anal squamous cell carcinoma (ASCC) is a rare neoplasm. Chemoradiotherapy is the standard of care, with no therapeutic advances achieved over the past three decades. Thus, a deeper molecular characterization of this disease is...
Read MoreUse of Purastat, a novel haemostatic matrix based on self-assembling peptides in the prevention of nasopharyngeal adhesion formation.
Purastat is a novel haemostatic agent that has recently been used effectively in nasal procedures, specifically in functional endoscopic endonasal surgery in the prevention of post-operative epistaxis while minimising adhesion...
Read MoreBAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that has long been considered to be a tumor suppressor in various tumors, including renal cell carcinoma, uveal melanoma, mesothelioma, and cutaneous melanoma....
Read MoreDoes early timing of lymph node surgery after resection of the primary tumour improve the clinical outcome of melanoma patients?
In patients with cutaneous melanoma (CM), the time span between resection of the primary tumour and sentinel lymph node biopsy (SLNB) as well as the subsequent interval between SLNB and complete lymph node dissection (CLND)...
Read MoreIt’s Time For Mohs: Micrographic Surgery For The Treatment Of High-Risk Basal Cell Carcinomas Of The Head And Neck Region.
Basal cell carcinoma (BCC) is the most common variety of non-melanoma skin cancer and its incidence is rising worldwide. The centrofacial sites (area H) are considered a high risk factor for BCC local recurrence. Mohs...
Read MoreHeat shock proteins regulating Toll-like receptors and the immune system could be a novel therapeutic target for melanoma.
Melanoma is a serious type of skin cancer, which develops in melanocyte cells. Although it is less common than some other skin cancers, it can be far more dangerous if not treated at an early stage because of its ability to...
Read MoreUpper Gastrointestinal Bleeding Due to a Duodenal Metastasis from Primary Testicular Squamous Cell Carcinoma.
BACKGROUND Primary squamous cell carcinoma of the testis (tSCC) is exceptionally rare. To date, only 5 cases have been described in the literature. We report the first case of upper gastrointestinal bleeding due to a duodenal...
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