Few prospective studies on outcomes in CSCC have been performed, and outcomes for patients treated...Read More
A series of different prodrugs of indoximod, including estesrs and peptide amides were synthesized with the aim of improving its oral bioavailability in humans. The pharmacokinetics of prodrugs that were stable in buffers,...Read More
Comprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma.
Anal squamous cell carcinoma (ASCC) is a rare neoplasm. Chemoradiotherapy is the standard of care, with no therapeutic advances achieved over the past three decades. Thus, a deeper molecular characterization of this disease is...Read More
Use of Purastat, a novel haemostatic matrix based on self-assembling peptides in the prevention of nasopharyngeal adhesion formation.
Purastat is a novel haemostatic agent that has recently been used effectively in nasal procedures, specifically in functional endoscopic endonasal surgery in the prevention of post-operative epistaxis while minimising adhesion...Read More
BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that has long been considered to be a tumor suppressor in various tumors, including renal cell carcinoma, uveal melanoma, mesothelioma, and cutaneous melanoma....Read More
Does early timing of lymph node surgery after resection of the primary tumour improve the clinical outcome of melanoma patients?
In patients with cutaneous melanoma (CM), the time span between resection of the primary tumour and sentinel lymph node biopsy (SLNB) as well as the subsequent interval between SLNB and complete lymph node dissection (CLND)...Read More
It’s Time For Mohs: Micrographic Surgery For The Treatment Of High-Risk Basal Cell Carcinomas Of The Head And Neck Region.
Basal cell carcinoma (BCC) is the most common variety of non-melanoma skin cancer and its incidence is rising worldwide. The centrofacial sites (area H) are considered a high risk factor for BCC local recurrence. Mohs...Read More
Heat shock proteins regulating Toll-like receptors and the immune system could be a novel therapeutic target for melanoma.
Melanoma is a serious type of skin cancer, which develops in melanocyte cells. Although it is less common than some other skin cancers, it can be far more dangerous if not treated at an early stage because of its ability to...Read More
Upper Gastrointestinal Bleeding Due to a Duodenal Metastasis from Primary Testicular Squamous Cell Carcinoma.
BACKGROUND Primary squamous cell carcinoma of the testis (tSCC) is exceptionally rare. To date, only 5 cases have been described in the literature. We report the first case of upper gastrointestinal bleeding due to a duodenal...Read More