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Patient and prescription factors associated with overdose after initiating opioids

1. Opioid overdoses were more frequent in those aged ≥75 or 18-24, who were male, Black, or had non-commercial insurance. Non-fatal opioid overdoses were more common in participants with comorbidities, prescribed long-acting opioids, received 6 opioid prescriptions in 6 months, or who filled opioid prescriptions at ≥3 pharmacies. 2. More opioid overdoses occurred in participants […]

Use of different sepsis scoring systems to predict mortality in bacteremic patients

1. Shapiro criteria and qSOFA scores significantly predicted sepsis-related mortality in bacteremic patients. 2. Model performance measures did not strongly support the independent use of sepsis criteria to screen for bacteremia in emergency departments. Evidence Level Rating: 2 (Good) While bacteremia associated with sepsis is associated with high mortality rates, prompt identification of sepsis and […]

Convalescent plasma is not effective at improving clinical outcomes or reducing mortality of COVID-19 patients not on mechanical ventilation

1. This meta-analysis found that treatment with COVID-19 convalescent plasma (CCP), compared to control group treatment, did not improve clinical outcomes, as measured by the World Health Organization clinical outcome score, or mortality. 2. There was an improvement in the mortality and clinical outcomes for participants treated with CCP who had a baseline WHO score […]

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