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Osteoporosis

Anti-inflammatory and osteoprotective effects of Chikusetsusaponin Ⅳa on rheumatoid arthritis via the JAK/STAT signaling pathway.

Nov 15, 2021

Rheumatoid arthritis (RA) is a common autoimmune disease, for which no economical and safe target drug treatment is available. Chikusetsusaponin Ⅳa (CS-IVa), an active compound in Panax japonicus C....

Identification and Prediction of Fatigue Trajectories in People With Rheumatoid Arthritis.

Nov 15, 2021

We aimed to identify groups demonstrating different long-term trajectories of fatigue among people with rheumatoid arthritis and determine baseline predictors for these trajectories.Our study included...

Augmenting Osteoporosis Imaging with Machine Learning.

Nov 08, 2021

In this paper, we discuss how recent advancements in image processing and machine learning (ML) are shaping a new and exciting era for the osteoporosis imaging field. With this paper, we want to give ...

Panaxynol induces fibroblast-like synovial cell apoptosis, inhibits proliferation and invasion through TLR4/NF-κB pathway to alleviate rheumatoid arthritis.

Nov 08, 2021

Panaxynol (PAL, PubChem CID: 5281149) is a common natural minor component in Umbelliferae plants, such as Radix Saposhnikoviae Divaricatae. Modern pharmacology studies show that PAL has nutritional va...

Sex Difference in Plasma Deoxyribonuclease Activity in Rats.

Nov 01, 2021

Extracellular DNA (ecDNA) activates immune cells and is involved in the pathogenesis of diseases associated with inflammation such as sepsis, rheumatoid arthritis or metabolic syndrome. DNA can be cle...

IgD promotes pannus formation by activating Wnt5A-Fzd5-CTHRC1-NF-κB signaling pathway in FLS of CIA rats and the regulation of IgD-Fc-Ig fusion protein.

Oct 25, 2021

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation, synovial hyperplasia, cartilage degeneration, bone erosion, and pannus. Immunoglobulin D (IgD) plays an ...

Does Combined Temporomandibular Joint Reconstruction With Patient-Fitted Total Joint Prosthesis and Orthognathic Surgery Provide Stable Skeletal and Occlusal Outcomes in Juvenile Idiopathic Arthritis Patients?

Oct 18, 2021

To determine skeletal and occlusal surgical changes and long-term stability outcomes for patients diagnosed with juvenile idiopathic arthritis (JIA) after TMJ reconstruction with TMJ Concepts patient-...

Types of vertebral fractures could influence the selection of clinical bone mineral measures to predict biomechanical properties.

Oct 18, 2021

Areal and volumetric BMD (aBMD and vBMD) measured by DXA and quantitative CT (QCT), respectively, are usually employed to predict vertebral fracture risks. In this study, we induced compression and we...

Administration of an adeno-associated viral vector expressing interferon-β in patients with inflammatory hand arthritis, results of a phase I/II study.

Oct 11, 2021

Inflammatory hand arthritis (IHA) results in impaired function. Local gene therapy with ART-I02, a recombinant adeno-associated viral (AAV) serotype 5 vector expressing interferon(IFN)-β, under the t...

ITGA2 Protein Is Associated with Rheumatoid Arthritis in Chinese and Affects Cellular Function of T Cells.

Oct 04, 2021

We identified proteins significant for rheumatoid arthritis (RA) in peripheral blood mononuclear cells (PBMCs), and to clarify mechanisms mediated by underlying proteins that may involve in the pathog...

Daphnes Cortex and its licorice-processed products suppress inflammation via the TLR4/NF-κB/NLRP3 signaling pathway and regulation of the metabolic profile in the treatment of rheumatoid arthritis.

Oct 04, 2021

Daphnes Cortex (Daphne Giraldii Nitsche, DGN) is a popular traditional Chinese herbal medicine for traumatic injuries and rheumatoid arthritis (RA) in the Shaanxi and Gansu provinces of China. Due to ...

Association between osteosarcopenia and cognitive frailty in older outpatients visiting a frailty clinic.

Sep 27, 2021

Osteosarcopenia and cognitive frailty are both risk factors for falls and fractures. The purpose of this study was to determine the association between osteosarcopenia and cognitive frailty.This was a...

Dynamics of local gene regulations in synovial fluid leukocytes from horses with lipopolysaccharide-induced arthritis.

Sep 27, 2021

The role of resident cells such a synoviocytes and chondrocytes in intra-articular inflammation is well-characterized, however the in vivo gene expression patterns of cells (predominantly leukocytes) ...

Primary total ankle replacement surgery is a cost-effective intervention.

Sep 20, 2021

The primary aim was to assess the cost-effectiveness of primary total ankle replacements (PTAR) in the UK. Secondary aim was to identify predictors associated with increased cost-effectiveness of PTAR...

Sarilumab monotherapy versus sarilumab and methotrexate combination therapy in patients with rheumatoid arthritis.

Sep 13, 2021

Sarilumab, as monotherapy or in combination with conventional synthetic DMARDs, such as methotrexate (MTX), has demonstrated improvement in clinical outcomes in patients with RA. The primary objective...

Joint involvement in canine visceral leishmaniasis: Orthopedic physical examination, radiographic and computed tomographic findings.

Sep 13, 2021

This study aimed to evaluate the joint involvement in dogs with visceral leishmaniasis by means of orthopedic physical examination, radiographic and computed tomographic (CT) findings. Of the 46 evalu...

The association between critical shoulder angle and revision following anatomic total shoulder arthroplasty: A matched case-control study.

Sep 06, 2021

The concept of the critical shoulder angle (CSA) was introduced in 2013 with studies showing larger CSA is associated with rotator cuff tears (RCT) and smaller CSA with glenohumeral osteoarthritis. Ho...

Results of Arthroscopic Rotator Cuff Repair for Calcific Tendonitis: A Comparative Analysis.

Sep 06, 2021

Outcomes following arthroscopic excision of calcific tendonitis and arthroscopic rotator cuff repair (CT-ARCR) are relatively limited without comparison analysis to standard arthroscopic rotator cuff ...

Microstructure and mechanical behaviors of tibia for collagen-induced arthritic mice treated with gingiva-derived mesenchymal stem cells.

Sep 06, 2021

Rheumatoid arthritis (RA) is a systemic polyarticular arthritis that primarily affects the small joints but also causes bone erosion in large joints. None of the currently existing treatment approache...

Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology.

Aug 30, 2021

Tripterygium hypoglaucum (levl.) Hutch (Celastraceae) (THH), as a traditional Chinese medicine, was clinically exploited to treat rheumatoid arthritis (RA), yet the underlying mechanism for this effec...