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Pneumonia

Vaccination in pediatric acquired inflammatory immune-mediated neuromuscular disorders.

Jan 10, 2022

To analyse literature data on vaccine related induction, worsening of the disease and disease reccurrences as well as vaccine safety and efficacy among pediatric patients with acquired inflammatory im...

Combined delivery of TLR2 and TLR7 agonists by Nanostructured Lipid Carriers Induces Potent Vaccine Adjuvant Activity in Mice.

Dec 20, 2021

Toll-like receptor (TLR) agonists are promising adjuvants and the combination of TLR agonists enhance immune responses by providing synergistic immune activity via triggering different signalling path...

Validation of algorithms for identifying outpatient infections in MS patients using electronic medical records.

Dec 20, 2021

Background Our multiple sclerosis (MS) stakeholder groups expressed concerns about whether MS disease-modifying therapies (DMTs) increase the risk of specific outpatient infections. Validated methods ...

Does mailing unsolicited HPV self-sampling kits to women overdue for cervical cancer screening impact uptake of other preventive health services in a United States integrated delivery system?

Nov 22, 2021

Women overdue for cervical cancer screening often have other preventive care gaps. We examined whether mailing unsolicited human papillomavirus (HPV) self-sampling kits to increase cervical cancer scr...

Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection.

Nov 15, 2021

Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapt...

Poor protective potential of influenza nucleoprotein antibodies despite wide prevalence.

Oct 25, 2021

Humans are exposed to influenza virus through periodic infections. Due to these repeated exposures, human populations commonly have elevated antibody titres targeting the conserved internal influenza ...

Sambucus nigra: A traditional medicine effective in reducing inflammation in mice.

Oct 18, 2021

Sambucus nigra L. is a plant of European origin and popularly known as elder, elderberry, black elder, European elder, European elderberry, and European black elderberry, being described in pharmacopo...

Role of expression of host cytokines in the pathogenesis of H9N2-PB2 reassortant and non-reassortant H5N1 avian influenza viruses isolated from crows in BALB/c mice.

Oct 18, 2021

The present experiment was conducted to study the role of cytokine, chemokine and TLRs responses of H9N2-PB2 reassortant H5N1 virus as compared to non-reassortant H5N1 virus isolated from crows in BAL...

The global proteome and ubiquitinome of bacterial and viral co-infected bronchial epithelial cells.

Oct 04, 2021

Viral infections facilitate bacterial trafficking to the lower respiratory tract resulting in bacterial-viral co-infections. Bacterial dissemination to the lower respiratory tract is enhanced by influ...

Single-virus content mixing assay reveals cholesterol-enhanced influenza membrane fusion efficiency.

Sep 20, 2021

In order to infect a cell, enveloped viruses must first undergo membrane fusion, which proceeds through a hemifusion intermediate, followed by the formation of a fusion pore through which the viral ge...

Emergence and adaptive evolution of influenza D virus.

Sep 20, 2021

As a novel member of the Orthomyxoviridae, influenza D virus (IDV) was firstly isolated from swine. However, cattle were found to serve as its primary reservoir. The study of IDV emergence can shed li...

Phase 1 open-label trial of intravenous administration of MVA-BN-brachyury-TRICOM vaccine in patients with advanced cancer.

Sep 06, 2021

MVA-BN-brachyury-TRICOM is a recombinant vector-based therapeutic cancer vaccine designed to induce an immune response against brachyury. Brachyury, a transcription factor overexpressed in advanced ca...

Influenza A viruses balance ER stress with host protein synthesis shutoff.

Sep 06, 2021

Excessive production of viral glycoproteins during infections poses a tremendous stress potential on the endoplasmic reticulum (ER) protein folding machinery of the host cell. The host cell balances t...

Exploring the epidemiological changes of common respiratory viruses since the COVID-19 pandemic: a hospital study in Hangzhou, China.

Sep 06, 2021

Adenovirus, respiratory syncytial virus, and influenza virus are common causes of respiratory infections. The COVID-19 pandemic had a significant impact on their prevalence. The aim of this study was ...

From influenza to SARS-CoV-2: etiological evaluation of acute benign childhood myositis.

Aug 26, 2021

To present the etiological evaluation results of our acute benign childhood myositis cases.Children, who were referred to pediatric neurology outpatient clinic in Maternity and Children's Hospital, wi...

Drug repurposing of dextromethorphan as a cellular target for the management of influenza.

Aug 26, 2021

Influenza viruses are responsible for seasonal epidemics and sporadic pandemics of varying severity in humans and additional treatment options are needed. High-throughput siRNA screens and an in-vivo ...

Biofilm Formation by Uropathogenic Escherichia coli: A Complicating Factor for Treatment and Recurrence of Urinary Tract Infections.

Aug 26, 2021

Uropathogenic Escherichia coli (UPEC) are the principal cause of urinary tract infections (UTIs) which can be either hospital- or community-acquired. The most crucial factor in the persistence and rec...

Tissue factor expression, extracellular vesicles and thrombosis after infection with the respiratory viruses influenza A virus and coronavirus.

Aug 23, 2021

Tissue factor (TF) is induced in a variety of cell types during viral infection, which likely contributes to disseminated intravascular coagulation and thrombosis. TF-expressing cells also release TF-...

Influenza and Anosmia: important prediction factors for severity and death of COVID-19.

Aug 23, 2021

To investigate the factors related to the severity and mo rtality of COVID-19 using big data-machine learning techniques.This study included 8070 patients in South Korea diagnosed with COVID-19 betwee...

Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines.

Aug 23, 2021

Self-amplifying RNA (saRNA) is a next-generation vaccine platform, but like all nucleic acids, requires a delivery vehicle to promote cellular uptake and protect the saRNA from degradation. To date, d...