Although multiple sclerosis (MS) is an immune-related disorder, pharmaceutical interventions targeting the immune system do not stop or reverse disability progression; the major challenge fo...
The balance of people with multiple sclerosis (PwMS) is commonly assessed during neurological examinations through clinical Romberg and tandem gait tests that are often not sensitive enough ...
The Rowland Universal Dementia Assessment Scale (RUDAS) is a cognitive test with favorable diagnostic properties for detecting dementia and a low influence of education and cultural biases.W...
Cognitive impairment is common in patients with multiple sclerosis, even in the early stages of the disease. The Brief International Cognitive Assessment for multiple sclerosis (BICAMS) is a...
The nine-hole peg test (NHPT) is the outcome measure with the least change in secondary and primary progressive MS (SPMS and PPMS) trials. The Standard NHPT is defined as the average of four...
Aquatic therapy improved both fatigue and balance in patients with MS and may provide an “optimal environment” for better outcomes in this patient population. Aquatic therapy may ...
For patients with MS, NP-led care as an add-on improved depression compared with usual care at 3 and 6 months, with no changes in satisfaction with care. Add-on nurse practitioner (NP...
Cognitive and motor function in MS are inherently related, and a multifaceted strategy may improve evaluation of deficits in these domains, even in early MS. “Cognitive and motor sy...
A review of data on how COVID-19 affects patients with MS shows that physicians should not delay treatment with disease-modifying therapies during the pandemic. Studies have suggested...
While many studies have examined spatial navigation among people who have experienced stroke or other forms of acquired brain injury, data on spatial navigation in patients with MS is highly...
Cuprizone (CPZ) is a copper chelator used to produce a reversible oligodendrocytopathy in animals, which has some similarities to the pathology found in human multiple sclerosis (MS). This m...
Fatigue in multiple sclerosis (MS) is a highly invalidating symptom with no pharmacological efficacious therapies, which furthermore present frequent severe side effects. In two previous ran...
A higher-quality diet may reduce disability progression and the risk for depression among patients with MS, according to an analysis of the Health Outcomes and Lifestyle in a Sample of Peopl...
Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disease caused by a mutation in the ABCD1 gene, producing mutations in the very long chain fatty acid transporter, ALD protein. Cerebral...
Blood-brain barrier (BBB) dysfunction has been recognized as an early pathological feature and contributing factor in multiple sclerosis. Endothelial-to-mesenchymal transition is a process a...
Epilepsy, multiple sclerosis (MS) and depression are long term, central nervous system disorders which have a significant impact on everyday life. Evaluating symptoms of these conditions is...
The ligand-sensing transcription factor Nurr1 emerges as a promising therapeutic target for neurodegenerative pathologies but Nurr1 ligands for functional studies and therapeutic validation ...
Relapsing-remitting MS (RRMS) is characterised by the patients' experience of periods of exacerbation in symptoms. The fear associated with the relapse influence the quality of life in patie...
Astrocytes (AST) play an important role in the pathogenesis of neurological disorders, and their activation is involved in the progression of multiple sclerosis (MS). (6aS, 10S, 11aR, 11bR, ...
Multiple sclerosis (MS) is an autoimmune disease characterized by white matter inflammatory demyelination in the central nervous system (CNS). Its clinical manifestations include decreased v...
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