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Multiple Sclerosis

Smartphone-Adapted Cognitive Monitoring Improves Detection of Clinical Changes in MS

Jul 19, 2022

Smartphone-based cognitive monitoring provided more detailed detection of clinical changes in patients with MS and could help individualize care for this group. Smartphone-adapted cognition mon...

MS Impacts Navigational Ability & Increases Spatial Anxiety

Jun 23, 2022

While many studies have examined spatial navigation among people who have experienced stroke or other forms of acquired brain injury, data on spatial navigation in patients with MS is highly limited. ...

Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?

May 23, 2022

Cuprizone (CPZ) is a copper chelator used to produce a reversible oligodendrocytopathy in animals, which has some similarities to the pathology found in human multiple sclerosis (MS). This model is at...

Home treatment against fatigue in multiple sclerosis by a personalized, bilateral whole-body somatosensory cortex stimulation.

May 23, 2022

Fatigue in multiple sclerosis (MS) is a highly invalidating symptom with no pharmacological efficacious therapies, which furthermore present frequent severe side effects. In two previous randomized co...

Diet Quality Influences Disability & Depression in MS

May 16, 2022

A higher-quality diet may reduce disability progression and the risk for depression among patients with MS, according to an analysis of the Health Outcomes and Lifestyle in a Sample of People with Mul...

Glycoprotein nonmetastatic melanoma protein B (GNMPB) as a novel biomarker for cerebral adrenoleukodystrophy.

May 16, 2022

Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disease caused by a mutation in the ABCD1 gene, producing mutations in the very long chain fatty acid transporter, ALD protein. Cerebral ALD (cALD...

Endothelial ETS1 inhibition exacerbate blood-brain barrier dysfunction in multiple sclerosis through inducing endothelial-to-mesenchymal transition.

May 16, 2022

Blood-brain barrier (BBB) dysfunction has been recognized as an early pathological feature and contributing factor in multiple sclerosis. Endothelial-to-mesenchymal transition is a process associated ...

Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals.

May 09, 2022

Epilepsy, multiple sclerosis (MS) and depression are long term, central nervous system disorders which have a significant impact on everyday life. Evaluating symptoms of these conditions is problemat...

Nurr1 Modulation Mediates Neuroprotective Effects of Statins.

May 02, 2022

The ligand-sensing transcription factor Nurr1 emerges as a promising therapeutic target for neurodegenerative pathologies but Nurr1 ligands for functional studies and therapeutic validation are lackin...

Negative interpretation of ambiguous bodily information by patients with relapsing-remitting multiple sclerosis.

Apr 25, 2022

Relapsing-remitting MS (RRMS) is characterised by the patients' experience of periods of exacerbation in symptoms. The fear associated with the relapse influence the quality of life in patients and th...

The matrine derivate MASM inhibits astrocyte reactivity and alleviates experimental autoimmune encephalomyelitis in mice.

Apr 25, 2022

Astrocytes (AST) play an important role in the pathogenesis of neurological disorders, and their activation is involved in the progression of multiple sclerosis (MS). (6aS, 10S, 11aR, 11bR, 11cS)-10-m...

Effectiveness of acupuncture for multiple sclerosis: A protocol for systematic review and meta-analysis.

Apr 18, 2022

Multiple sclerosis (MS) is an autoimmune disease characterized by white matter inflammatory demyelination in the central nervous system (CNS). Its clinical manifestations include decreased vision, dip...

Cross-sectional and longitudinal correlations between the Arm Function in Multiple Sclerosis Questionnaire (AMSQ) and other outcome measures in multiple sclerosis.

Apr 18, 2022

The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) is the first validated disease specific patient-reported outcome measure (PROM) designed to assess upper extremity function in patients with...

Real-life evidence of treatment with alemtuzumab in patients diagnosed with relapsing-remitting multiple sclerosis in Colombia.

Apr 11, 2022

Physical disability, cognitive impairment, depression, and fatigue are poorly understood in Latin American patients with multiple sclerosis following alemtuzumab infusion.To describe Sustained changes...

Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges.

Apr 04, 2022

Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a ha...

Alterations of subset and cytokine profile of peripheral T helper cells in PBMCs from Multiple Sclerosis patients or from individuals with MS risk SNPs near genes CYP27B1 and CYP24A1.

Mar 28, 2022

T helper cells play an important role in the aetiology of Multiple Sclerosis (MS). Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of...

Inter-joint coordination during gait in people with multiple sclerosis: A focus on the effect of disability.

Mar 21, 2022

Walking difficulties, which are widespread among people with MS (pwMS), represent one of the major factors contributing to physical disability and, as such, may greatly affect an individual's independ...

Artemisinin derivative TPN10466 suppresses immune cell migration and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.

Mar 14, 2022

Multiple sclerosis (MS) was one of the major conditions causing neurological dysfunction and was an incurable progressive central nervous system disease. Experimental autoimmune encephalomyelitis (EAE...

A paradigm shift: Bioengineering meets mechanobiology towards overcoming remyelination failure.

Mar 14, 2022

Therapeutic strategies aimed at overcoming the loss of myelin sheath in central nervous system demyelinating diseases are often unsuccessful due to nescience underlying the mechanisms of remyelination...

7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2/ARE signaling.

Mar 07, 2022

Rheumatoid arthritis (RA) is an chronic autoimmune disease and characterized by high incidence. However, there is no effective therapies for RA. Therefore, it is urgent to discover new drugs for RA tr...