For Patients With MS, Group Behavioral Telehealth Program May Lead to Weight Loss
Participating in a group behavioral telehealth program may improve the ability of patients with MS to achieve clinically meaningful weight loss....
Multiple Sclerosis
Authoritative medical articles, news, research, and guidelines pertaining to Multiple Sclerosis.
Providing meaningful interpretation of performance outcome measures by co-calibration with patient-reported outcomes through the Rasch model: illustration with multiple sclerosis measures.
Performance outcome (PerfO) measures are based on tasks performed by patients in a controlled environment, making their meaningful interpretation challenging to establish. Co-calibrating Per...
Sickness Absence Rate Increases Years Before MS Onset
Researchers observed an increased risk of sick leave in patients with MS several years before clinical onset of the disease....
Early Intensive Treatment Enhances Long-Term Clinical Outcomes
Results of a registry study confirmed that early intensive treatment enhances long-term clinical outcomes by minimizing the accumulation of neurological damage. ...
Biological Onset Precedes Clinical Onset of MS by Years
The onset of MS-related progressive brain tissue loss (PBTL) precedes clinical disease onset by 5 to 6 years. ...
Fenebrutinib Associated With Rapid MS Lesion Reduction
Fenebrutinib penetrates cerebrospinal fluid at sufficient enough levels to reduce activation of B-cells and microglia in vitro....
Prioritizing Highly Effective Therapies in Children With MS
Highly effective therapies as a first-line option in pediatric-onset MS results in sustained reduction of clinical and radiological disease activity over 5 years....
Chi-Separation to Evaluate Dynamic Changes in Early MS Lesions
Younger patients with MS have more tissue destruction in white matter lesions but also a higher capacity for remyelination....
FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS) that is characterized by myelin damage, followed by axonal and ultimately neuronal ...
The presence of Mott cells in the lymph nodes of rats with experimental autoimmune encephalomyelitis.
Mott cells are plasma cells that have multiple spherical Russell bodies packed in their cytoplasm. Russell bodies are dilated endoplasmic reticulum cisternae filled with aggregates of immuno...
Cancer risk, disease-modifying therapy, and age in multiple sclerosis: A retrospective population-based cohort study.
Long-term population-based safety studies are needed to investigate cancer outcomes in people with multiple sclerosis (MS) treated with modern disease-modifying therapy (DMT).To investigate ...
Applicability of multiple quantitative magnetic resonance methods in genetic brain white matter disorders.
Magnetic resonance imaging (MRI) measures of tissue microstructure are important for monitoring brain white matter (WM) disorders like leukodystrophies and multiple sclerosis. They should be...
Multimodal agility-based exercise training (MAT) versus strength and endurance training (SET) to improve multiple sclerosis-related fatigue and fatigability during inpatient rehabilitation: a randomized controlled pilot and feasibility study [ReFEx].
Multimodal agility-based exercise training (MAT) is a group-based exercise training framework for persons with multiple sclerosis (pwMS) with a potential to impact fatigue and fatigability. ...
Altered T cell development in an animal model of multiple sclerosis.
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS), leading to demyelination and axonal degeneration. Experimental autoimmune encephalomyel...
Imidazo[2,1-b]thiazole Based Indoleamine-2,3-dioxygenase (IDO)-1 Inhibitor: Structure Based Design, Synthesis, Bio-evaluation and Docking Studies.
Indoleamine-2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme known to catalyse the initial and rate limiting step of kynurenine pathway of L-tryptophan metabolism. IDO1 enzyme over exp...
In MS, Exercise Plus Coaching May Improve Atherosclerosis
An exercise program for patients with MS that included regular remote coaching improved cardiovascular and respiratory health....
Radiologically isolated syndrome.
Individuals can be deemed to have radiologically isolated syndrome (RIS) if they have incidental demyelinating-appearing lesions in their brain or spinal cord that are highly suggestive of m...
AGR - 3 Epilepsy Surgical Planning in a Patient with Co-Morbid Multiple Sclerosis and Seizures.
Research increasingly points to historically unappreciated cortical effects of multiple sclerosis (MS), with two-fold elevated risk of seizures. Nevertheless, epilepsy only occurs in 2-5% of...
A - 16 Performance on the SDMT Predicts Functionality in Older Adults.
The Symbol Digit Modalities Test (SDMT) is a task of processing speed and executive functioning that is widely used to evaluate individuals with Multiple Sclerosis (MS) and has been shown to...
Exosomes in multiple sclerosis and Alzheimer's disease - adversary and ally.
Neuroinflammation and the resulting neurodegeneration is a big challenge for the healthcare system, especially with the aging population. Neuroinflammation can result from a variety of insul...
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