Hematology
Jul 28, 2022
1. Hemophilia B patients treated with the adeno-associated virus (AAV) gene therapy produced dose-dependent sustained factor IX levels. 2. All patients required immunosuppression with glucocorticoids ...
Jul 28, 2022
1. Hypericin photodynamic therapy was found to be more efficacious in treating early-stage T cell lymphoma lesions compared to placebo. 2. Common adverse events include mild skin and application site ...
Jul 28, 2022
1. IV tenecteplase was non-inferior to IV alteplase for treatment of acute ischemic stroke regarding the primary outcome of a mRS of 0-1 after 90-120 days post-treatment. 2. Adverse events, including ...
Jul 22, 2022
1. This retrospective cohort study demonstrated that for a given blood oxygen hemoglobin saturation, Black, Asian, and Hispanic patients in the intensive care unit had higher pulse oximetry readings t...
Jul 21, 2022
1. In this prospective cohort study, isolated distal deep vein thrombosis (IDDVT) was linked to lower all-cause mortality and fewer venous thromboembolism (VTE) deterioration events compared to proxim...
Jul 21, 2022
1. Fewer patients in the thrombectomy group achieved an MRS score of 0-2 at 90 days compared to thrombectomy with alteplase (57% vs. 65%). 2. Thrombectomy with alteplase resulted in significantly incr...
Jul 21, 2022
1. Fewer patients in the direct thrombectomy achieved functional independence at 90 days compared to the bridging therapy group. 2. Safety outcomes such as intracerebral hemorrhage and death were simi...
Jul 06, 2022
1. Sickle cell trait was associated with increased COVID-19 mortality and various preexisting chronic medical conditions, particularly in persons of African ancestry. 2. These findings support the inc...
Jun 30, 2022
1. Median event-free survival in the liso-cel group was significantly greater than in the standard-of-care group (10.1 months vs. 2.3 months). 2. Grade 3 or worse neutropenia was more common among the...
Jun 30, 2022
1. Patients with the ACKR1 variant (CC genotype) had an elevated risk of azathioprine discontinuation attributed to hematopoietic toxicity. 2. The CC genotype group remained at elevated risk after adj...
Jun 22, 2022
Physicians should have discussions with their patients with CML who are considering discontinuing a TKI and those who experience pain after stopping a TKI. “Past clinical trials have shown th...
May 30, 2022
1. New-onset atrial fibrillation following hospitalization for community acquired pneumonia was associated with higher subsequent thromboembolic risk. Evidence Rating Level: 1 (Excellent) Study Rundow...
May 23, 2022
In 2019, the Dana Farber/Mass General Brigham Hematology-Oncology Fellowship redesigned the 6-month Hematology training track/curriculum required for all fellows seeking to double board in hematology ...
May 23, 2022
Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and chronic kidney injuries. This study aimed to analyze the prevalence of renal disorders i...
May 17, 2022
Patients with clinically progressive MM have worse outcomes compared with biochemically progressive MM, but earlier therapy initiation can mean better outcomes. “For patients with a...
May 16, 2022
Blood cancers are characterized by pathological disorders causing uncontrolled hematological cell division. Various strategies were previously explored for the treatment of blood cancers, including ch...
May 11, 2022
1. Compared to placebo, mitapivat was found to be effective in treating hemolytic anemia and increasing hemoglobin levels. 2. Mitapivat was found to be safe with acceptable adverse event profiles for ...
May 09, 2022
Acquired pure red cell aplasia (PRCA) is a rare syndrome characterized by anemia with reticulocytopenia and a marked reduction in erythroid precursors. Given its rarity, the true incidence is largely ...
May 02, 2022
The reduction of ROS and inflammatory factor levels plays important role in the treatment of colitis. A series of ROS-responsive lipids (ZnDPA-R) based on the thioketal structure were designed and syn...
