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Hematology

Low-dose AAVS3 gene therapy is efficacious for treating patients with hemophilia B

Jul 28, 2022

1. Hemophilia B patients treated with the adeno-associated virus (AAV) gene therapy produced dose-dependent sustained factor IX levels. 2. All patients required immunosuppression with glucocorticoids ...

Topical hypericin photodynamic therapy is effective and safe in early-stage T cell lymphoma

Jul 28, 2022

1. Hypericin photodynamic therapy was found to be more efficacious in treating early-stage T cell lymphoma lesions compared to placebo. 2. Common adverse events include mild skin and application site ...

Intravenous tenecteplase non-inferior to alteplase for thrombolysis in acute ischemic stroke

Jul 28, 2022

1. IV tenecteplase was non-inferior to IV alteplase for treatment of acute ischemic stroke regarding the primary outcome of a mRS of 0-1 after 90-120 days post-treatment. 2. Adverse events, including ...

Racial and ethnic discrepancies in pulse oximetry performance associated with reduced oxygen supplementation

Jul 22, 2022

1. This retrospective cohort study demonstrated that for a given blood oxygen hemoglobin saturation, Black, Asian, and Hispanic patients in the intensive care unit had higher pulse oximetry readings t...

Isolated distal deep vein thrombosis linked to better long-term outcomes than proximal deep vein thrombosis

Jul 21, 2022

1. In this prospective cohort study, isolated distal deep vein thrombosis (IDDVT) was linked to lower all-cause mortality and fewer venous thromboembolism (VTE) deterioration events compared to proxim...

Thrombectomy alone is inferior to thrombectomy plus alteplase for acute ischemic stroke

Jul 21, 2022

1. Fewer patients in the thrombectomy group achieved an MRS score of 0-2 at 90 days compared to thrombectomy with alteplase (57% vs. 65%). 2. Thrombectomy with alteplase resulted in significantly incr...

Bridging therapy is superior to direct thrombectomy within 4.5 hours of acute ischemic stroke

Jul 21, 2022

1. Fewer patients in the direct thrombectomy achieved functional independence at 90 days compared to the bridging therapy group. 2. Safety outcomes such as intracerebral hemorrhage and death were simi...

Sickle cell trait associated with preexisting kidney comorbidities and increased COVID-19 mortality

Jul 06, 2022

1. Sickle cell trait was associated with increased COVID-19 mortality and various preexisting chronic medical conditions, particularly in persons of African ancestry. 2. These findings support the inc...

Lisocabtagene maraleucel improves survival for relapsed or refractory large B-cell lymphoma

Jun 30, 2022

1. Median event-free survival in the liso-cel group was significantly greater than in the standard-of-care group (10.1 months vs. 2.3 months). 2. Grade 3 or worse neutropenia was more common among the...

ACKR1 variant increases risk of azathioprine-related hematopoietic toxicity

Jun 30, 2022

1. Patients with the ACKR1 variant (CC genotype) had an elevated risk of azathioprine discontinuation attributed to hematopoietic toxicity. 2. The CC genotype group remained at elevated risk after adj...

Managing Pain After Discontinuing Treatment for Leukemia

Jun 22, 2022

Physicians should have discussions with their patients with CML who are considering discontinuing a TKI and those who experience pain after stopping a TKI. “Past clinical trials have shown th...

New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk

May 30, 2022

1. New-onset atrial fibrillation following hospitalization for community acquired pneumonia was associated with higher subsequent thromboembolic risk. Evidence Rating Level: 1 (Excellent) Study Rundow...

Putting the Heme Back in Heme-Onc: an Evaluation of the Redesigned Hematology Track within the Dana Farber/Mass General Brigham Hematology-Oncology Fellowship.

May 23, 2022

In 2019, the Dana Farber/Mass General Brigham Hematology-Oncology Fellowship redesigned the 6-month Hematology training track/curriculum required for all fellows seeking to double board in hematology ...

Risk factors for renal impairment in patients with hematological cancer receiving antineoplastic treatment.

May 23, 2022

Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and chronic kidney injuries. This study aimed to analyze the prevalence of renal disorders i...

Biochemical & Clinical Progression Outcomes in MM

May 17, 2022

Patients with clinically progressive MM have worse outcomes compared with biochemically progressive MM, but earlier therapy initiation can mean better outcomes.   “For patients with a...

Therapeutic Role of Carotenoids in Blood Cancer: Mechanistic Insights and Therapeutic Potential.

May 16, 2022

Blood cancers are characterized by pathological disorders causing uncontrolled hematological cell division. Various strategies were previously explored for the treatment of blood cancers, including ch...

Mitapivat efficacious in treating pyruvate kinase deficiency

May 11, 2022

1. Compared to placebo, mitapivat was found to be effective in treating hemolytic anemia and increasing hemoglobin levels. 2. Mitapivat was found to be safe with acceptable adverse event profiles for ...

Incidence of Acquired Pure Red Cell Aplasia: A Nationwide Epidemiologic Analysis With 2 Registry Databases in Japan.

May 09, 2022

Acquired pure red cell aplasia (PRCA) is a rare syndrome characterized by anemia with reticulocytopenia and a marked reduction in erythroid precursors. Given its rarity, the true incidence is largely ...

#VisualAbstract: Canakinumab treatment did not reduce pain to clinical significance but shows anti-inflammatory effects in children and young adults with sickle cell anemia

May 05, 2022

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Zn-Dipicolylamine-based Reactive Oxygen Species-Responsive Lipids for siRNA Delivery and in vivo Colitis Treatment.

May 02, 2022

The reduction of ROS and inflammatory factor levels plays important role in the treatment of colitis. A series of ROS-responsive lipids (ZnDPA-R) based on the thioketal structure were designed and syn...