Efficient therapies are available for the treatment of osteoporosis. Anti-resorptive therapies, including bisphosphonates and denosumab increase bone mineral density (BMD) and reduce the risk of fractures by 20-70%. Bone-forming...Read More
Lumbar intervertebral disc characterization through quantitative MRI analysis: An automatic voxel-based relaxometry approach.
To develop an automated pipeline based on convolutional neural networks to segment lumbar intervertebral discs and characterize their biochemical composition using voxel-based relaxometry, and establish local associations with...Read More
Emerging evidence highlights the role of the long noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing. Osteoblast proliferation, migration, and survival are pivotal during this process. In this study, we aimed to improve our...Read More
Pulsed Radiofrequency Treatment for Bertolotti’s Syndrome Presenting with Low Back Pain: Report of Four Cases.
Pulsed radiofrequency (PRF) has been used successfully to treat myriad types of chronic pain, including spinal radicular pain and that associated with facet arthropathy. Although there are a few reports about radiofrequency...Read More
Modulation of pain perception by oxytocin (OXT) has attracted increased scientific and clinical interest. Neural mechanisms underlying these effects are poorly understood. In this study, we aimed to investigate the effects of...Read More
Use of portfolios in teaching communication skills and professionalism for Portuguese-speaking medical students.
This study aimed to analyse the effect of a portfolio with three activities fostering students’ reflection, self-efficacy and teaching of communication skills and professionalism.A cross-sectional study was applied with a...Read More
The Wickerhamiella/Starmerella clade – a treasure trove for the study of the evolution of yeast metabolism.
The Wickerhamiella and Starmerella genera form a clade (W/S clade) that branches close to Yarrowia lipolytica in the Saccharomycotina species tree. It comprises approximately 90 recognized species and 50 putative new species not...Read More
Conservation and expansion of a necrosis-inducing small secreted protein family from host-variable phytopathogens of the Sclerotiniaceae.
Fungal effector proteins facilitate host-plant colonization and have generally been characterized as small secreted proteins (SSPs). We classified and functionally tested SSPs from the secretomes of three closely related...Read More
Orientin and isoorientin are C-glycosidic flavonoids, considered as markers of some plant species as Passiflora edulis var. flavicarpa Degener and reported in the literature to have pharmacological properties. In order to...Read More