Advertisement

Arthritis

Mental health conditions and the risk of chronic opioid therapy among patients with rheumatoid arthritis: a retrospective veterans affairs cohort study.

Feb 10, 2020

Patients with rheumatoid arthritis (RA) often receive opioid analgesics for pain management. We examined the association between mental health conditions and the risk of chronic opioid therapy.A retro...

Benefits of exercise in patients with rheumatoid arthritis: a randomized controlled trial of a patient-specific exercise programme.

Feb 10, 2020

Patients with rheumatoid arthritis (RA) tend to be more overweight, take less physical exercise, exhibit decreased cardiorespiratory fitness and demonstrate reduced muscle strength compared with age- ...

Diffuse large B-cell lymphoma involving the left sternoclavicular joint mimicking rheumatoid arthritis flare: a case-based review.

Feb 10, 2020

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting primarily joints and an increased risk of developing malignant lymphomas in RA has been well reported. However, primary lymphoma in ...

The role of socioeconomic status in the susceptibility to develop systemic lupus erythematosus in Mexican patients.

Feb 04, 2020

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well-identified as risk factors. SLE patients have different phenot...

microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5.

Feb 04, 2020

The research aims to explore the roles and underlying mechanisms of microRNA-21 (miR-21) in lipopolysaccharide (LPS)-induced inflammation in MH7A cells. Cells were treated with LPS and/or transfected ...

Autoantibodies against P29ING4 are associated with complex regional pain syndrome.

Feb 04, 2020

Complex regional pain syndrome (CRPS) is a complication following trauma or surgery and may be difficult to diagnose since biomarkers are lacking. Using protein array technology, we found antibodies b...

Experience of musculoskeletal ultrasound scanning improves physicians' physical examination skills in assessment of synovitis.

Feb 04, 2020

Musculoskeletal ultrasound (US) is more sensitive than physical examination in detecting synovitis and helps physicians to understand its pathophysiology. In this study, we aimed to determine if the e...

Is background methotrexate advantageous in extending TNF inhibitor drug survival in elderly patients with rheumatoid arthritis? An analysis of the British Society for Rheumatology Biologics Register.

Jan 31, 2020

To evaluate drug survival with monotherapy compared with combination therapy with MTX in RA older adults.Patients from the British Society for Rheumatology Biologics Register, a prospective observatio...

Validated LC-MS/MS method for quantitation of a selective JAK1 inhibitor, filgotinib in rat plasma and its application to a pharmacokinetic study in rats.

Jan 31, 2020

Filgotinib is a selective JAK1 (Janus kinase) inhibitor, filed in Japan for the treatment of rheumatoid arthritis. In this paper we are reporting a validated LC-MS/MS (liquid chromatography coupled wi...

Age of onset as an influencing factor for disease severity in children with familial Mediterranean fever.

Jan 31, 2020

To define the demographic, clinical and genetic features of familial Mediterranean fever (FMF) patients with early disease onset and to compare them with late-onset FMF patients. Patients were divide...

Conventional versus ultrasound treat to target: no difference in magnetic resonance imaging inflammation or joint damage over 2 years in early rheumatoid arthritis.

Jan 31, 2020

To investigate whether an ultrasound-guided treat-to-target strategy for early RA would lead to reduced MRI inflammation or less structural damage progression compared with a conventional treat-to-tar...

MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2.

Jan 31, 2020

Humoral immune responses initiate in the lymph node draining the site of viral infection (dLN). Some viruses subvert LN B cell activation; however, our knowledge of viral hindrance of B cell responses...

Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse.

Jan 30, 2020

To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission a...

Mismatch between the impact of disease perceived by patients and the state of clinical remission assessed by physicians in psoriatic arthritis.

Jan 30, 2020

Both the evaluation of disease activity and the assessment of the impact of the disease on patients' lives are subjects of intense research at present in psoriatic arthritis (PsA). We aimed to test th...

Performance of the 2016 ACR/EULAR Sjögren's syndrome classification criteria in patients with secondary Sjögren's syndrome.

Jan 30, 2020

To evaluate the performance of the 2016 ACR-EULAR classification Sjögren's syndrome (SS) criteria for classifying patients with secondary SS.We randomly selected 300 patients with systemic lupus eryt...

Inhibition of glycogen synthase kinase-3β protects against collagen type II-induced arthritis associated with the inhibition of miR155/24 and inflammation and upregulation of apoptosis in rats.

Jan 30, 2020

MicroRNAs have been implicated in the pathogenesis of rheumatoid arthritis (RA) and their syntheses are modulated by glycogen synthase kinase-3β (GSK-3β). Therefore, we hypothesised that the GSK-3β...

Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production.

Jan 30, 2020

Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by ex...

Overdose, Relapse After Buprenorphine Discontinuation High

Dec 27, 2019

The longer patients continue with buprenorphine treatment, the lower their risk of adverse outcomes.   THURSDAY, Dec. 26, 2019 (HealthDay News) -- Buprenorphine treatment may be needed ...