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Pain General

Mismatch between the impact of disease perceived by patients and the state of clinical remission assessed by physicians in psoriatic arthritis.

Jan 30, 2020

Both the evaluation of disease activity and the assessment of the impact of the disease on patients' lives are subjects of intense research at present in psoriatic arthritis (PsA). We aimed to test th...

Performance of the 2016 ACR/EULAR Sjögren's syndrome classification criteria in patients with secondary Sjögren's syndrome.

Jan 30, 2020

To evaluate the performance of the 2016 ACR-EULAR classification Sjögren's syndrome (SS) criteria for classifying patients with secondary SS.We randomly selected 300 patients with systemic lupus eryt...

Inhibition of glycogen synthase kinase-3β protects against collagen type II-induced arthritis associated with the inhibition of miR155/24 and inflammation and upregulation of apoptosis in rats.

Jan 30, 2020

MicroRNAs have been implicated in the pathogenesis of rheumatoid arthritis (RA) and their syntheses are modulated by glycogen synthase kinase-3β (GSK-3β). Therefore, we hypothesised that the GSK-3β...

The features and burden of headaches within a chiropractic clinical population: A cross-sectional analysis.

Jan 30, 2020

The aim of this study is to a) investigate the headache features and level of headache severity, chronicity, and disability found within a chiropractic patient population and b) to ascertain if patien...

Menstrual Migraine: What it is and Does it Matter?

Jan 30, 2020

The diagnostic criteria of menstrual migraine (MM), migraine related to menstruation and pure menstrual migraine, are placed in the appendix of the International Classification of Headache Disorders a...

Characterization of Ubrogepant

Jan 30, 2020

A growing body of evidence has implicated the calcitonin gene-related peptide (CGRP) receptors in migraine pathophysiology. With the recent approval of monoclonal antibodies targeting CGRP or the CGRP...

[The efficacy of the second generation triptan migrepam in the treatment of migraine attacks: results of the comparative study].

Jan 30, 2020

To evaluate the efficacy and safety of migrepam in the treatment of migraine attacks.Sixty patients with episodic migraine with and without aura, aged between 18 and 65 years, were included in the ran...

Intravenous Endothelin-1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura.

Jan 30, 2020

To investigate whether intravenously infused provokes migraine aura and migraine headache in migraine patients with aura.Migraine with aura has been associated with endothelial dysfunction and increas...

Impact of Melatonin on Skeletal Muscle and Exercise

Jan 30, 2020

Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life. Preventive and therapeutic tools to limit onset and progression o...

Sleep and Pain in Subjects with Fibromyalgia and Comorbid Insomnia: Double-blind, Crossover, Study of Suvorexant 20 mg versus Placebo.

Jan 30, 2020

The chronic pain disorder, fibromyalgia, is associated with sleep disturbance, typically sleep maintenance. No studies have evaluated the effect of sleep medication on pain sensitivity in this populat...

Primary Pulmonary MALT Lymphoma: A Case Report and Literature Review.

Jan 30, 2020

Primary pulmonary MALT (mucosa-associated lymphoid tissue) lymphoma is a rare entity that imposes a rigorous and demanding diagnostic work-up.We present the case of a 74-year-old female non-smoker wit...

Use of Complementary and Integrative Therapies by Fibromyalgia Patients

Jan 30, 2020

To reevaluate the frequency and pattern of complementary and integrative medicine (CIM) use in patients with fibromyalgia (FM).Consecutive patients with FM who were referred to the Mayo Clinic fibromy...

Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production.

Jan 30, 2020

Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by ex...

Neural substrates for post-stroke complex regional pain syndrome type I: a retrospective case-control study using voxel-based lesion symptom mapping analysis.

Jan 30, 2020

Post-stroke Complex Regional Pain Syndrome (CRPS) is characterized by swelling, pain and changes in the skin that appear on the affected wrist and hand. In this retrospective study, we analyzed the re...

Outcomes of Prescription Opioid Dose Escalation for Chronic Pain

Jan 30, 2020

The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms asso...

Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis?

Jan 30, 2020

Non-invasive measures of neuroinflammatory processes in humans could substantially aid diagnosis and therapeutic development for many disorders, including chronic pain. Several proton Magnetic Resonan...

Shared liability to pain, common mental disorders, and long-term work disability differs among women and men.

Jan 27, 2020

Knowledge of factors involved in the associations between pain, common mental disorders and future work incapacity is still scarce. The aim of this study was to examine the overlap between genetic and...

c-Jun/p38MAPK/ASIC3 pathways specifically activated by NGF through TrkA is crucial for mechanical allodynia development.

Jan 27, 2020

Mechanical allodynia is a cardinal sign of several inflammatory pain disorders where Nerve Growth Factor, a prototypic neurotrophin, plays a crucial role by binding to TrkA receptors. Here, we took th...

Neck Pain and Headache Following Whiplash Injury

Jan 27, 2020

Neck pain and headache are two of the most common complications of whiplash injury. Therefore, we performed a systematic literature search on PubMed and Embase for publications reporting on the preval...

Pharmacological characterization of a rat Nav1.7 loss-of-function model with insensitivity to pain.

Jan 27, 2020

Sodium channel Nav1.7, encoded by the SCN9A gene, is a well validated target that plays a key role in controlling pain sensation. Loss-of-function mutations of Nav1.7 can cause a syndrome of profound ...

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