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Pain General

Effectiveness of Arthroscopically Assisted Surgery for Ankle Arthrodesis.

Jan 02, 2023

Regarding the treatment of ankle arthritis, the choice of arthroscopic ankle arthrodesis (AAA) or open ankle arthrodesis (OAA) remains controversial. To guide clinical decision-making, we conducted a ...

Sex dimorphism in Resolvin D5-induced analgesia in rat models of trigeminal pain.

Jan 02, 2023

Resolvin D5 (RvD5) is a specialized pro-resolving lipid mediator with potent anti-inflammatory and analgesic properties. Orofacial pain conditions, especially those that are chronic, present clinical ...

Na1.7 Channel Blocker [Ala, Phe, Leu, Arg]GpTx-1 Attenuates CFA-induced Inflammatory Hypersensitivity in Rats via Endogenous Enkephalin Mechanism.

Jan 02, 2023

Venom-derived Na1.7 channel blockers have promising prospects in pain management. The 34-residue tarantula peptide GpTx-1 is a potent Na1.7 channel blocker. Its powerful analog [Ala, Phe, Leu, Arg]GpT...

Veterans Affairs Bereaved Family Survey: Psychometric Evaluation

Dec 20, 2022

The following is a summary of "Psychometric Evaluation of the Veterans Affairs Bereaved Family Survey in Community Nursing Homes" published in the December 2022 issue of Pain and Symptom Management by...

COVID-19: Video and In-Person Palliative Care Delivery Challenges

Dec 20, 2022

The following is a summary of "Video and In-Person Palliative Care Delivery Challenges before and during the COVID-19 Pandemic" published in the December 2022 issue of Pain and Symptom Management by C...

Palliative Radiotherapy: Goals and Prognostic Understanding

Dec 20, 2022

The following is a summary of "Prognostic Understanding and Goals of Palliative Radiotherapy: A Qualitative Study" published in the December 2022 issue of Pain and Symptom Management by Chen et al. ...

Knowledge, experiences, and attitudes of Australian General Practitioners towards medicinal cannabis: a 2021-2022 survey.

Dec 19, 2022

Medicinal cannabis (MC) products have been available on prescription in Australia for around six years. General practitioners (GPs) are at the forefront of MC prescribing and recent years have seen su...

Psychological Characteristics of Juvenile Fibromyalgia Syndrome.

Dec 19, 2022

The aim of the study was to compare psychological characteristics of adolescent patients with Juvenile Fibromyalgia Syndrome (JFM) with individuals suffering from chronic pain (CP) due to headache or ...

Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats.

Dec 19, 2022

Neuropathic pain is a refractory pain state, and its mechanism is still not clear. Previous studies have shown that the purine receptor P2X4R expressed on hyperactive microglia in the spinal cord is e...

The Association of Coronary Artery Calcium Score and Osteoporosis in Postmenopausal Women: A Cross-Sectional Study.

Dec 19, 2022

The association between osteoporosis, a common metabolic bone disorder, and atherosclerosis has been reported in different studies. In this study, we aimed to investigate the association between the c...

Gene selection by incorporating genetic networks into case-control association studies.

Dec 19, 2022

Large-scale genome-wide association studies (GWAS) have been successfully applied to a wide range of genetic variants underlying complex diseases. The network-based regression approach has been develo...

Predicting placebo analgesia in patients with chronic pain using natural language processing: a preliminary validation study.

Dec 19, 2022

Patients with chronic pain show large placebo effects in clinical trials, and inert pills can lead to clinically meaningful analgesia that can last from days to weeks. Whether the placebo response can...

Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial.

Dec 19, 2022

Readily accessible nonpharmacological interventions that can assist in opioid dose reduction while managing pain is a priority for adults receiving long-term opioid therapy (LOT). Few large-scale eval...

All of Us Research Program: Unrelieved Symptom Predictors in Patients With Chronic Conditions

Dec 14, 2022

The following is a summary of "Predictors of Unrelieved Symptoms in All of Us Research Program Participants With Chronic Conditions" published in the December 2022 issue of Pain and Symptom Management...

Clinical Characteristics of Dysphagia in Solid Tumors Outside the Neck, Head, & Upper GI Tract

Dec 14, 2022

The following is a summary of "Dysphagia in Solid Tumors Outside the Head, Neck or Upper GI Tract: Clinical Characteristics" published in the December 2022 issue of Pain and Symptom Management by Kenn...

Patients with Ovarian Cancer: Race, Affordability and Utilization of Supportive Care

Dec 14, 2022

The following is a summary of "Race, Affordability and Utilization of Supportive Care in Ovarian Cancer Patients" published in the September 2022 issue of Pain and Symptom Management by Anyanwu et al....

The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor.

Dec 12, 2022

It has been thought that μ-opioid receptors (MOPs) activate the G protein-mediated analgesic pathway and β-arrestin 2-mediated side effect pathway; however, ligands that only minimally recruit β-ar...

Fibromyalgia Presents With A Straight Neck on Radiograph

Dec 09, 2022

Barring any other radiographic abnormalities, a straight neck may be a major anatomical aberration in fibromyalgia that has gone unnoticed. Robert Katz, MD, spoke with Physician’s Weekly abo...

Cancer Pain Treatment: Preferences of Patients for Rescue Medications

Dec 08, 2022

For a study, researchers sought to examine Chinese cancer patients' risk-benefit preferences for rescue medications (RD) and their willingness to pay (WTP) in the treatment of breakthrough cancer pain...

Severe Cancer Pain Treatment Using Intravenous Oxycodone Rapid Titration

Dec 08, 2022

For a study, researchers sought to evaluate the effectiveness of titrating the dosage of oxycodone intravenously in treating severe cancer pain. The second goal was the oral route's conversion ratio, ...

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