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Pain General

Sunlight exposure, sun-protective behaviour, and anti-citrullinated protein antibody positivity: A general population-based study in Quebec, Canada.

Sep 24, 2020

To examine associations between sunlight exposure and anti-citrullinated protein antibodies (ACPA) using general population data in Quebec, Canada.A random sample of 7600 individuals (including 786 po...

Ubiquitination in rheumatoid arthritis.

Sep 24, 2020

Rheumatoid arthritis is a chronic, inflammatory joint disease leading to inflammation of synovial membrane that lines the joints. This inflammation further progresses and results in destruction of joi...

Functional impairment and disability among patients with migraine: evaluation of galcanezumab in a long-term, open-label study.

Sep 21, 2020

Migraine can negatively impact patient functioning and quality of life. Here, we report the effects of galcanezumab (GMB), a humanized monoclonal antibody that binds to calcitonin gene-related peptide...

Effect of Migraine on Pregnancy Planning: Insights From the American Registry for Migraine Research.

Sep 21, 2020

To evaluate the effect of migraine on women's pregnancy plans.Participants were enrolled in the American Registry for Migraine Research, an observational study that recruits patients from headache spe...

Motivations to initiate injectable hydromorphone and diacetylmorphine treatment: A qualitative study of patient experiences in Vancouver, Canada.

Sep 21, 2020

Within the context of the ongoing overdose crisis and limitations of conventional opioid treatments, the scale-up of injectable hydromorphone (HDM) and diacetylmorphine (DAM) as evidenced-based treatm...

Individual and social network correlates of recent treatment for substance use disorders among persons who use drugs in Baltimore, MD (2014 - 2017).

Sep 21, 2020

This analysis examined individual and network correlates of treatment enrollment for substance use disorders (SUDs) in the past 6 months and whether these factors varied by type(s) of drug(s) used and...

A Systematic Review of Arthroscopic Versus Open Debridement of the Arthritic Elbow.

Sep 21, 2020

To systematically review the available data with regard to clinical and functional outcomes of arthroscopic and open debridement for elbow arthritis in order to determine the complication rate with tr...

Patients' perceptions of the pathways linking chronic pain with problematic substance use.

Sep 21, 2020

Approximately one-half of patients with substance use disorders (SUD) experience chronic pain. Yet how patients perceive the relationship between their substance use and chronic pain remains poorly un...

Optimized acupuncture treatment (acupuncture and intradermal needling) for cervical spondylosis-related neck pain: a multicenter randomized controlled trial.

Sep 21, 2020

Cervical spondylosis (CS)-related neck pain is difficult to treat due to its degenerative nature. The aim of this nine-center, single-blinded, randomized controlled trial was to evaluate the efficacy ...

Neuropathic pain: clinical classification and assessment in patients with pain due to cancer.

Sep 21, 2020

Neuropathic cancer pain (NcP) is associated with worse treatment responses and specific therapy indications, but a standardized clinical diagnosis of NcP is still lacking.This is a prospective observa...

Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double-blind, placebo-controlled, phase 3b trial.

Sep 21, 2020

Many patients who require migraine preventive treatment have not been able to tolerate or have not responded to multiple previous preventive medications. We aimed to assess the safety and efficacy of ...

MiR103a-3p and miR107 are related to adaptive coping in a cluster of fibromyalgia patients.

Sep 21, 2020

MicroRNA (miRNA) mainly inhibit post-transcriptional gene expression of specific targets and may modulate disease severity.We aimed to identify miRNA signatures distinguishing patient clusters with fi...

Comparison of patient-led, fibromyalgia-orientated physical activity and a non-specific, standardised 6-month physical activity program on quality of life in individuals with fibromyalgia: a protocol for a randomised controlled trial.

Sep 21, 2020

Exercise has been shown to significantly improve pain and function in individuals with fibromyalgia. Research into the effectiveness of exercise is often based on standardised exercise programmes that...

Fibromyalgia in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: prevalence and screening.

Sep 21, 2020

To explore the prevalence, clinical characteristics, and screening strategy for fibromyalgia (FM) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.A total of 3...

PF-06410293: An Adalimumab Biosimilar.

Sep 21, 2020

PF-06410293 (Amsparity/Abrilada) is a biosimilar of the anti-tumor necrosis factor (TNF)-α antibody adalimumab. It is approved for use in all indications for which adalimumab is approved, including i...

Pain Responses to Protease-Activated Receptor-2 Stimulation in the Spinal Cord of Naïve and Arthritic Rats.

Sep 21, 2020

There is strong evidence showing that the activation of peripheral proteinase-activated receptors type 2 (PAR-2) can initiate hyperalgesic and inflammatory responses in the joint. However, to date, th...

A risk score for postoperative nausea and/or vomiting in women undergoing cesarean delivery with intrathecal morphine.

Sep 21, 2020

Postoperative nausea/vomiting affects up to 80% of parturients undergoing cesarean delivery, but there is a lack of obstetric-specific risk-prediction models. We performed this study to identify posto...

A Multifaceted Approach to Opioid Education, Prescribing, and Disposal for Patients with Breast Cancer Undergoing Surgery.

Sep 17, 2020

Standardized prescribing practices are recommended to decrease opioid abuse, however, data regarding the handling and disposal of leftover narcotics are lacking. This quality improvement project and a...

Development and validation of a clinical prediction score for poor postoperative pain control following elective spine surgery.

Sep 17, 2020

Thirty percent to sixty-four percent of patients experience poorly controlled pain following spine surgery, leading to patient dissatisfaction and poor outcomes. Identification of at-risk patients bef...

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial.

Sep 17, 2020

Observational studies have shown a link between zinc deficiency and migraine headaches. We aimed to examine the effect of zinc supplementation on the characteristics of migraine attacks in patients wi...

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