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Pain General

Subsequent neoplasms in childhood cancer survivors.

Jul 20, 2020

The aim of the study was to characterize subsequent neoplasm (SN) (malignant (SMN), benign (BSNs), and non-melanoma skin cancer (NMSC)) treated previously for a childhood solid malignant tumor at the ...

Postpartum NSAID Use and Adverse Outcomes among Women with Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-analysis.

Jul 20, 2020

 This study was aimed to perform a systematic review and meta-analysis of the association between postpartum nonsteroidal anti-inflammatory drug (NSAID) use among women with hypertensive disorders o...

Opioid Use Disorder Is Associated with an Increased Risk of Infection after Total Joint Arthroplasty: A Large Database Study.

Jul 16, 2020

Recent studies have shown that patients with opioid use disorder have impaired immunity. However, few studies with large patient populations have evaluated the risks of surgical site infection (SSI) a...

Study protocol for Long-Term Opioid Therapy in Spine Center Outpatients: The Spinal Pain Opioid Cohort (SPOC).

Jul 16, 2020

Spinal pain is the leading worldwide cause of patient-years lived with chronic pain and disability. While opioids are well documented as an effective short-term pain-relieving medication, more than a ...

The Efficacy and Safety of DFN-15 for the Treatment of Migraine: A Meta-Analysis of Randomized Controlled Studies.

Jul 16, 2020

The efficacy of DFN-15 for pain control of migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of DFN-15 versus placebo on pain control in migrain...

Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight/obesity.

Jul 16, 2020

Pain catastrophizing and cutaneous allodynia represent two risk factors for greater headache-related disability. Yet, there is limited knowledge of the extent to which these risk factors are modifiabl...

Stroke-like migraine attacks after radiation therapy (SMART) syndrome-a case series and review.

Jul 16, 2020

Cranial irradiation is used both prophylactically and for the treatment of brain tumors. There are various complications associated with it. The rare complication of stroke-like migraine attacks after...

Syrian female war refugees: preliminary fibromyalgia and insomnia screening and treatment trends.

Jul 16, 2020

Fibromyalgia (FM) is a chronic disorder characterised by chronic widespread pain, fatigue and sleep disturbances with higher prevalence in females. Psychological factors contribute largely to FM. Alth...

A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia.

Jul 16, 2020

Alterations in cellular energy metabolism have been implicated in chronic pain suggesting a role for mitochondrial DNA (mtDNA). Previous studies reported associations of a limited number of mtDNA poly...

Gulf war illness, post-HPV vaccination syndrome, and Macrophagic Myofasciitis. Similar disabling conditions possibly linked to vaccine-induced autoimmune dysautonomia.

Jul 16, 2020

More than one-fourth of all Persian Gulf War coalition soldiers remain seriously ill. Several epidemiological studies suggest a link between multiple vaccinations at the time of the military operation...

The International Spinal Cord Injury Survey: The Way Forward.

Jul 16, 2020

As a community survey of people living with spinal cord injury in 22 countries, representing all six of WHO regions of the world, InSCI is one of a very few surveys that highlights, not only the basic...

The cervical spine as a predominant site of cerebrospinal fluid leak: Preliminary results using the overflow leak test.

Jul 16, 2020

Cerebrospinal fluid hypovolemia (CSFH) is usually treated via an epidural blood patch (EBP). Accurate placement of the EBP at the site of cerebrospinal fluid (CSF) leakage is required for the successf...

Opioid Prescribing Patterns After Anorectal Surgery.

Jul 16, 2020

Anorectal procedures are frequently performed and have the potential to be particularly painful. There are no evidence-based guidelines regarding opioid prescribing after anorectal surgery and limited...

Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis.

Jul 16, 2020

TNF plays a key role in immune-mediated inflammatory diseases including rheumatoid arthritis (RA) and spondyloarthritis (SpA). It remains incompletely understood how TNF can lead to different disease ...

Media supplementation for targeted manipulation of monoclonal antibody galactosylation and fucosylation.

Jul 16, 2020

Monoclonal antibodies (mAbs) are critically important biologics as the largest class of molecules used to treat cancers, rheumatoid arthritis, and other chronic diseases. Antibody glycosylation is a c...

Testosterone protects against the development of widespread muscle pain in mice.

Jul 16, 2020

Chronic widespread pain conditions are more prevalent in women than men suggesting a role for gonadal hormones in the observed differences. Previously, we showed female mice, compared to male, develop...

Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion.

Jul 16, 2020

Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compare...

Offset analgesia identifies impaired endogenous pain modulation in pediatric chronic pain disorders.

Jul 16, 2020

Offset analgesia (OA), a psychophysical test of endogenous pain inhibition, is diminished in many adult chronic pain disorders but OA has not been investigated in youth with chronic pain disorders. Th...

30-day Readmissions and Reoperations after Total Elbow Arthroplasty: A National Database Study.

Jul 16, 2020

The purpose of this study was to determine the rate of short-term complications after TEA and identify predictors of readmission and reoperation. We hypothesized that TEA performed for acute elbow tra...

The state of the science in opioid policy research.

Jul 13, 2020

Characterize the state of the science in opioid policy research based on a literature review of opioid policy studies.We conducted a scoping review of studies evaluating the impact of U.S. state-level...

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