To investigate the demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma.
A retrospective national population-based study SETTING: UK 1995-2015 POPULATION: A total of 234 women with a diagnosis of gestational choriocarcinoma, in the absence of a prior molar pregnancy, managed at the UKs two gestational trophoblast centres in London and Sheffield.
Retrospective review of the patient’s demographic and clinical data. Comparison with contemporary UK birth and pregnancy statistics.
Incidence statistics for non-molar choriocarcinoma across the maternal age groups. Cure rates for patients by FIGO prognostic score group.
Over the 21-year study period there were a total of 234 cases of non-molar gestational choriocarcinoma, giving an incidence of 1:66,775 relative to live births and 1:84,226 to viable pregnancies. For women aged under 20 the incidence relative to viable pregnancies was 1:223,494, for ages 30-34 1:80,227 and for ages 40-45 1:41,718. Treatment outcomes indicated an overall 94.4% cure rate. Divided by FIGO prognostic groups, the cure rates were low risk group 100%, high risk 96%, and ultra-high risk 80.5%.
Non-molar gestational choriocarcinoma is a very rare diagnosis with little prior detailed information on the demographics and natural history. The data in this study gives age related incidence data based on a large national population study. The results also demonstrated the widely varying natural history of this rare malignancy and the marked correlation of disease incidence with rising maternal age.

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