To evaluate the diagnostic performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index based on Cirrus high-definition optical coherence tomography to discriminate early glaucomatous eyes from normal eyes in clinical practice.
Evaluation of diagnostic test or technology.
Ninety-eight patients with early glaucoma and 98 age-matched normal subjects.
Macular ganglion cell-inner plexiform layer (GCIPL) thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters were measured in each subject. The measurements were run through the UNC OCT algorithm to compare their diagnostic abilities.
Area under the curve (AUC) of the receiver operating characteristic and sensitivity at 95% specificity.
The AUC of the UNC OCT Index was 0.974. The best AUCs of the single parameters were those of minimum GCIPL (0.926) of macular GCIPL, average RNFL (0.916) of peripapillary RNFL, and rim area (0.964) of ONH. The AUC of the UNC OCT Index was significantly greater than those of minimum GCIPL, average RNFL (all P < 0.05), and also outperformed rim area. The sensitivity value of UNC OCT Index (90.8) was greater than that of single OCT parameters (minimum GCIPL [42.9], average RNFL [64.3], rim area [84.7]) at 95% specificity.
The diagnostic performance of the UNC OCT Index in discriminating early glaucomatous eyes from normal eyes is high and exceeds the best ONH, peripapillary RNFL, and macular GCIPL parameters in clinical practice.

Copyright © 2022. Published by Elsevier Inc.