We collected data from the registers of 566HIV positives. A retrospective cohort study design was employed. Data entered into EpiInfo™7 and analyzed using SPSS Version 20. Tuberculosis incidence density was determined per 100 person-years.Time-to-event distributions estimated using Kaplan-Meier estimates. Survival curves and hazards across different categories compared using log-rank tests. Determinants identified using Cox proportional hazard models. For the hazard ratio, 95%CI was computed. A P-value <0.05 in the multivariable analysis was considered statistically significant.
A total of 566 HIV positives were followed for 2140.08 person-years, giving tuberculosis incidence density rate of 6.82/100 person-years (146,25.8%). The highest incidence observed within the first year of follow-up. Independent determinants were large family size (AHR = 1.783,95%CI = 1.113-2.855), lower baseline CD4 (AHR = 2.568,95%CI = 1.602-4.116), and baseline body mass index<18.5 (AHR = 1.907,95%CI = 1.530-2.690). Enrolled in anti-retroviral treatment (AHR = 0.066,95%CI = 0.045-0.98) and taking isoniazid prophylaxis treatment (AHR = 0.202, 95%CI = 0.108-0.380) had a protective effect.
Tuberculosis is still a major cause of morbidity among HIV positive individuals. Early HIV diagnosis, enrollment on anti-retroviral treatment and isoniazid prophylaxis treatment should be considered to decrease tuberculosis risk.
Copyright © 2020. Published by Elsevier Ltd.