To investigate the independent prognostic factors and establish survival prediction model for advanced oral squamous cell carcinoma (OSCC).
At the time of admission, the general information and past medical history of 177 patients with advanced OSCC were collected in detail. All patients underwent radical resection. After surgery, radiotherapy and chemotherapy with hydroxycampothecin (HCPT) and pingyangmycin (PYM) were performed according to the patient’s condition. All patients were followed up for 5 years after surgery, and the survival rate during that period and the risk factors for prognosis were analyzed. The data were analyzed by SPSS 20.0 software package.
During the follow-up period, 2 patients died due to other causes, 4 were excluded due to lost to follow-up, 42 of the remaining 111 patients died, 69 survived, the total survival rate was 62.16%. The survival status of patients with advanced OSCC with different age, T stage and M stage had no significant difference (P>0.05), while significant difference was found among patients with different gender, tissue differentiation degree, N stage and chemotherapy (P<0.05). Gender, N stage and HCPT in combination of PYM chemotherapy were independent risk factors (P<0.05), while histological differentiation degree was not an independent risk factor for survival of patients (P>0.05). The survival curves of gender, N stage and HCPT in combination of PYM chemotherapy had certain predictive value on the survival of patients with advanced OSCC.
Gender, N stage and HCPT in combination of PYM chemotherapy are independent risk factors for the survival of patients with advanced OSCC, and their survival curves can be used as a survival prediction model.