The analysis included patients who received GLE/PIB for 8 weeks selected from the EpiTer-2 database, large retrospective national real-world study evaluating antiviral treatment in 12,584 individuals in 22 Polish hepatology centres.
A total of 1,034 patients with female predominance (52%) were enrolled in the analysis. The majority of them were treatment-naïve (94%), presented liver fibrosis (F) of F0-F3 (92%), with the most common GT1b, followed by GT3. The overall sustained virologic response after exclusion of non-virologic failures was achieved in 95.8% and 98% respectively (p=0.19). In multivariate logistic regression HCV GT-3 (beta=0.07, p=0.02) and HIV infection (beta=-0.14, p<0.001) were independent predictors of non-response.
We demonstrated high effectiveness of 8-week GLE/PIB treatment in a non-GT3 population irrespective of liver fibrosis stage. Comparable efficacy was achieved in non-cirrhotic patients regardless of the genotype, including GT3 HCV.
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