Long non-coding RNAs (lncRNAs) play an essential role in multitudinous physiological and pathological processes, including vascular disease. We previously showed that lncRNA (enst00000511042) is upregulated in endothelial progenitor cells (EPCs) of deep veni thrombosis (DVT) patients. Here, we investigate the role and mechanism of in EPCs and DVT. Using the DVT model, we found that significantly reduced the thrombus size and weight and enhanced the homing ability of EPC to DVT sites to promote resolution and recanalization of thrombus. promoted cell cycle progression, proliferation, migration and invasion in EPCs, enhanced EPC angiogenesis and , and inhibited apoptosis. Strikingly, this study showed that was unbalanced and modulated Forkhead Box Protein O1 (FOXO1) in EPCs in patients with DVT by interacting with . Mechanistically, functions as a sponge of , which targets FOXO1. Both knockdown and overexpression remarkably inhibited angiogenesis, migration and invasion in EPCs. Additionally, our data suggested that activated the Akt pathway and enhanced fibroblast growth factor 2 (FGF2), matrix metalloproteinase-2/9 (MMP2/9) and F-actin expression. Taken together, this study indicates that modulates angiogenesis, proliferation and homing ability of EPCs via regulating FGF2 and MMP2/9 expression through the /FOXO1/Akt pathway, which may provide a new direction for the development of DVT therapeutics.
Risk factors of unplanned neurosurgery for scoliotic patients with Chiari malformation type I and syringomyelia after spinal deformity correction.
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Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia.
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- ACC 2020The American College of Cardiology decided to cancel ACC.20/WCC due to COVID-19, which was scheduled to take place March 28-30 in Chicago. However, ACC.20/WCC Virtual Meeting continues to release cutting edge science and practice changing updates for cardiovascular professionals on demand and free through June 2020.
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